Mäenpää Kimmo, Leppänen Matti T, Figueiredo Kaisa, Tigistu-Sahle Feven, Käkelä Reijo
Department of Biology, University of Eastern Finland, P.O. Box 111, FI-80101, Joensuu, Finland,
Arch Environ Contam Toxicol. 2015 Jan;68(1):193-203. doi: 10.1007/s00244-014-0071-1. Epub 2014 Aug 17.
Knowledge on the internal distribution of halogenated organic chemicals (HOCs) would improve our understanding of dose-effect relationships and subsequently improve risk assessment of contaminated sites. Herein, we determine the concentrations of HOCs based on equilibrium partitioning in storage lipids, membrane lipids, and proteins in field-contaminated fish using equilibrium sampling devices. The study shows the importance of protein as a sorptive phase in lean fish. Our results provide a basis for using species-specific equilibrium partitioning coefficients between sorptive tissues and fish internal water as a substitute for K(ow) in, for example, upgrading models that simulate food-chain accumulation of the chemical.
了解卤代有机化合物（HOCs）在体内的分布情况，将有助于我们更好地理解剂量-效应关系，进而改进对污染场地的风险评估。在此，我们使用平衡采样装置，基于野外受污染鱼类储存脂质、膜脂质和蛋白质中的平衡分配来测定HOCs的浓度。该研究表明蛋白质作为瘦鱼中的吸附相的重要性。我们的结果为使用吸附组织与鱼体内水之间的物种特异性平衡分配系数替代辛醇-水分配系数（K(ow)）奠定了基础，例如，用于升级模拟该化学品食物链积累的模型。
