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编码前列腺素内过氧化物合酶的人类基因的克隆及该酶的一级结构

Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme.

作者信息

Yokoyama C, Tanabe T

机构信息

Department of Pharmacology, National Cardiovascular Center Research Institute, Osaka, Japan.

出版信息

Biochem Biophys Res Commun. 1989 Dec 15;165(2):888-94. doi: 10.1016/s0006-291x(89)80049-x.

DOI:10.1016/s0006-291x(89)80049-x
PMID:2512924
Abstract

The complete amino acid sequence of human prostaglandin endoperoxide synthase (EC 1.14.99.1, cyclooxygenase) was deduced by cloning and sequence analysis of human genomic DNA coding for the enzyme. The isolated clones covered approximately 40 kilobase pairs of human gene and the protein coding region of the enzyme was distributed into eleven exons, which encoded 599 amino acid residues with a calculated molecular weight of 68,548. Human prostaglandin endoperoxide synthase exhibited 91% amino acid identity with the sheep enzyme.

摘要

通过对编码人前列腺素内过氧化物合酶（EC 1.14.99.1，环氧化酶）的人基因组DNA进行克隆和序列分析，推导得到了该酶完整的氨基酸序列。分离得到的克隆覆盖了约40千碱基对的人基因，该酶的蛋白质编码区分布在11个外显子中，这些外显子编码599个氨基酸残基，计算分子量为68548。人前列腺素内过氧化物合酶与绵羊酶的氨基酸同一性为91%。

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