Cancel-Tassin Geraldine, Romana Marc, Gaffory Cecile, Blanchet Pascal, Cussenot Olivier, Multigner Luc
CeRePP, Pitié-Salpêtrière Hospital, Paris 75013; ER2, UPMC Univ Paris 6, Paris 75020, France, .
Asian J Androl. 2015 Jan-Feb;17(1):117-9. doi: 10.4103/1008-682X.135127.
Multiple regions of the genome have been associated with the risk of prostate cancer in Caucasians, particularly including several polymorphisms located at 8q24. Region 2 of 8q24 has been repeatedly found to be associated with the risk of prostate cancer among men of African descent, although one study performed in the Caribbean island of Jamaica did not report this finding. In this study, the single nucleotide polymorphism rs16901979, located in region 2 of 8q24, was genotyped in 498 cases of histologically confirmed prostate cancer and 541 controls from the French Caribbean islands of Guadeloupe, where the population is largely of African descent. The AA genotype and the A allele at rs16901979 were associated with elevated risks of prostate cancer (odds ratios [ORs] = 1.84, 95% confidence interval [95% CI] = 1.26-2.69, P = 0.002 and OR = 1.36, 95% CI = 1.13-1.64, P = 0.001, respectively). Following stratification of the patients by disease aggressiveness, as defined by the Gleason score, the pooled genotypes AC + AA were associated with a higher risk of a Gleason score ≥7 at diagnosis (OR = 1.79, 95% CI = 1.17-2.73, P = 0.007). In summary, the A allele at rs16901979 was associated with the risk of prostate cancer in the Caribbean population of Guadeloupe, confirming its involvement in populations of African descent. Moreover, our study provides the first evidence of an association between this variant and the risk of aggressive prostate cancer.
基因组的多个区域已被证实与高加索人患前列腺癌的风险相关，尤其是位于8q24的几个多态性位点。尽管在加勒比海岛屿牙买加进行的一项研究未报告这一发现，但8q24区域2已被反复发现与非洲裔男性患前列腺癌的风险相关。在本研究中，对来自法属加勒比岛屿瓜德罗普岛的498例经组织学确诊的前列腺癌患者和541例对照进行了基因分型，该地区人群主要为非洲裔，所检测的单核苷酸多态性rs16901979位于8q24区域2。rs16901979的AA基因型和A等位基因与前列腺癌风险升高相关（优势比[ORs]=1.84，95%置信区间[95%CI]=1.26 - 2.69，P = 0.002；OR = 1.36，95%CI = 1.13 - 1.64，P = 0.001）。根据Gleason评分定义的疾病侵袭性对患者进行分层后，合并基因型AC + AA与诊断时Gleason评分≥7的较高风险相关（OR = 1.79，95%CI = 1.17 - 2.73，P = 0.007）。总之，rs16901979的A等位基因与瓜德罗普岛加勒比人群患前列腺癌的风险相关，证实了其在非洲裔人群中的作用。此外，我们的研究首次证明了该变异与侵袭性前列腺癌风险之间的关联。
