Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 217 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA.
Cancer Epidemiol Biomarkers Prev. 2011 Jan;20(1):23-32. doi: 10.1158/1055-9965.EPI-10-0698. Epub 2010 Nov 11.
Genome-wide association studies (GWAS) have identified numerous prostate cancer susceptibility alleles, but these loci have been identified primarily in men of European descent. There is limited information about the role of these loci in men of African descent.
We identified 7,788 prostate cancer cases and controls with genotype data for 47 GWAS-identified loci.
We identified significant associations for SNP rs10486567 at JAZF1, rs10993994 at MSMB, rs12418451 and rs7931342 at 11q13, and rs5945572 and rs5945619 at NUDT10/11. These associations were in the same direction and of similar magnitude as those reported in men of European descent. Significance was attained at all reported prostate cancer susceptibility regions at chromosome 8q24, including associations reaching genome-wide significance in region 2.
We have validated in men of African descent the associations at some, but not all, prostate cancer susceptibility loci originally identified in European descent populations. This may be due to the heterogeneity in genetic etiology or in the pattern of genetic variation across populations.
The genetic etiology of prostate cancer in men of African descent differs from that of men of European descent.
全基因组关联研究（GWAS）已经确定了许多前列腺癌易感基因，但这些基因座主要是在欧洲血统的男性中发现的。关于这些基因座在非洲裔男性中的作用，信息有限。
我们确定了 7788 例前列腺癌病例和具有 47 个 GWAS 确定的基因座基因型数据的对照。
我们在 JAZF1 处的 SNP rs10486567、MSMB 处的 rs10993994、11q13 处的 rs12418451 和 rs7931342 以及 NUDT10/11 处的 rs5945572 和 rs5945619 处鉴定出了显著的关联。这些关联与在欧洲血统男性中报道的关联方向和幅度相似。在 8q24 染色体上的所有报告的前列腺癌易感区域都达到了显著水平，包括在区域 2 中达到全基因组显著水平的关联。
我们在非洲裔男性中验证了一些但不是所有最初在欧洲血统人群中发现的前列腺癌易感基因座的关联。这可能是由于遗传病因或不同人群中遗传变异模式的异质性所致。
非洲裔男性的前列腺癌遗传病因与欧洲裔男性不同。
