利用 iCOGS 定制基因分型阵列鉴定 23 个新的前列腺癌易感性位点。
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
机构信息
The Institute of Cancer Research, Sutton, UK.
出版信息
Nat Genet. 2013 Apr;45(4):385-91, 391e1-2. doi: 10.1038/ng.2560.
Abstract
Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genome-wide significance (P < 5 × 10(-8)). More than 70 prostate cancer susceptibility loci, explaining ∼30% of the familial risk for this disease, have now been identified. On the basis of combined risks conferred by the new and previously known risk loci, the top 1% of the risk distribution has a 4.7-fold higher risk than the average of the population being profiled. These results will facilitate population risk stratification for clinical studies.
摘要
在发达国家，前列腺癌是男性中最常见的癌症。为了鉴定常见的前列腺癌易感等位基因，我们对来自国际 PRACTICAL 联盟的 25074 例前列腺癌病例和 24272 例对照的血液 DNA 中的 211155 个 SNP 进行了基因分型，这些 SNP 位于定制的 Illumina 阵列(iCOGS)上。在全基因组显著水平(P < 5 × 10(-8))鉴定出 23 个新的前列腺癌易感位点。现在已经鉴定出超过 70 个前列腺癌易感位点，解释了该疾病约 30%的家族风险。基于新的和以前已知的风险位点所带来的综合风险，风险分布的前 1%比正在分析的人群的平均风险高出 4.7 倍。这些结果将有助于为临床研究进行人群风险分层。
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