Vejrazkova Daniela, Lukasova Petra, Vankova Marketa, Vcelak Josef, Bradnova Olga, Cirmanova Veronika, Andelova Katerina, Krejci Hana, Bendlova Bela
Department of Molecular Endocrinology, Institute of Endocrinology, 11694 Prague 1, Czech Republic.
Institute for Mother and Child Care, Prague, 14710 Prague 4, Czech Republic.
Int J Endocrinol. 2014;2014:508923. doi: 10.1155/2014/508923. Epub 2014 Jul 15.
The gene MTNR1B encodes a receptor for melatonin. Melatonin receptors are expressed in human β-cells, which implies that genetic variants might affect glucose tolerance. Meta-analysis confirmed that the rs10830963 shows the most robust association. The aim of the study was to assess the rs10830963 in Czech GDM patients and controls and to study relations between the SNP and biochemical as well as anthropometric characteristics. Our cohort consisted of 880 women; 458 were diagnosed with GDM, and 422 were normoglycemic controls without history of GDM. Despite similar BMI, the GDM group showed higher WHR, waist circumference, abdominal circumference, and total body fat content. The risk allele G was more frequent in the GDM group (38.3 versus 29.4% in controls, OR 1.49 CI95% [1.22; 1.82]; P OR = 0.0001). In spite of higher frequency, the G allele in the GDM group was not associated with any markers of glucose metabolism. In contrast, controls showed significant association of the allele G with FPG and with postchallenge glycemia during the oGTT. Frequency analysis indicates that rs10830963 is involved in gestational diabetes in Czech women. However, the association of the SNP with glucose metabolism, which is obvious in controls, is covert in women who have experienced GDM.
基因MTNR1B编码褪黑素受体。褪黑素受体在人类β细胞中表达，这意味着基因变异可能会影响葡萄糖耐量。荟萃分析证实，rs10830963显示出最强的关联性。本研究的目的是评估捷克妊娠期糖尿病（GDM）患者和对照组中的rs10830963，并研究该单核苷酸多态性（SNP）与生化及人体测量学特征之间的关系。我们的队列由880名女性组成；458名被诊断为GDM，422名是无GDM病史的血糖正常对照组。尽管体重指数（BMI）相似，但GDM组的腰臀比（WHR）、腰围、腹围和全身脂肪含量更高。风险等位基因G在GDM组中更为常见（对照组为38.3%，而对照组为29.4%，比值比（OR）为1.49，95%置信区间（CI）[1.22；1.82]；P OR = 0.0001）。尽管频率较高，但GDM组中的G等位基因与任何葡萄糖代谢标志物均无关联。相比之下，对照组中该等位基因G与空腹血糖（FPG）以及口服葡萄糖耐量试验（oGTT）期间的餐后血糖存在显著关联。频率分析表明，rs10830963与捷克女性的妊娠期糖尿病有关。然而，该SNP与葡萄糖代谢的关联在对照组中很明显，而在患有GDM的女性中则不明显。
