Ashraf Mohd, Shahzad Naveed, Irshad Mohd, Hussain Sheikh Quyoom, Ahmed Parvez
Pediatric Nephrology Division, Department of Pediatrics, GB Pant Hospital, Government Medical College Srinagar, Jammu and Kashmir, India.
Indian J Crit Care Med. 2014 Aug;18(8):518-26. doi: 10.4103/0972-5229.138156.
The recent standardization and validation of definitions of pediatric acute kidney injury (pAKI) has ignited new dimensions of pAKI epidemiology and its risk factors. pAKI causes increased morbidity and mortality in critically ill-children. Among the hospitalized patients incidence of pAKI ranges from 1% to 31%, while mortality ranges from 28% to 82%, presenting a broad range due to lack of uniformly acceptable pAKI definition. In addition, cumulative data regarding the progression of pAKI to chronic kidney disease in children is rising. Despite these alarming figures, treatment modalities have failed to deliver significantly. In this review, we will summarize the latest developments of pAKI and highlight important aspects of pAKI management.
小儿急性肾损伤（pAKI）定义的近期标准化和验证开启了pAKI流行病学及其危险因素的新维度。pAKI会导致危重症儿童的发病率和死亡率增加。在住院患者中，pAKI的发病率为1%至31%，死亡率为28%至82%，由于缺乏统一认可的pAKI定义，数据差异很大。此外，关于儿童pAKI进展为慢性肾脏病的累积数据也在增加。尽管这些数字令人担忧，但治疗方式并未取得显著成效。在本综述中，我们将总结pAKI的最新进展，并强调pAKI管理的重要方面。
