Siew Edward D, Furth Susan L
Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Division of Nephrology, Perelman School of Medicine at the University of Pennsylvania, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Kidney Int. 2014 Mar;85(3):494-5. doi: 10.1038/ki.2013.389.
Hospitalized children are experiencing acute kidney injury (AKI) with increasing frequency and are especially vulnerable to its long-term complications. Attempts to leverage novel biomarkers to improve phenotyping of this disease are limited by untargeted testing within broadly selected populations. Here, we review efforts by Basu et al. to use readily available clinical information to identify critically ill children at higher risk for developing severe AKI, who may benefit from novel diagnostic and prognostic information.
住院儿童患急性肾损伤（AKI）的频率越来越高，且特别容易出现其长期并发症。试图利用新的生物标志物来改善这种疾病的表型分析，受到广泛选定人群中无针对性检测的限制。在此，我们回顾了巴苏等人的研究成果，他们试图利用现有的临床信息，来识别重症AKI高危儿童，这些儿童可能会从创新性诊断和预后信息中受益。
