Kan Andrey, Hodgkin Philip D
Immunology Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052 Australia ; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010 Australia.
Syst Synth Biol. 2014 Sep;8(3):215-21. doi: 10.1007/s11693-014-9149-3. Epub 2014 Apr 29.
The acute adaptive immune response is complex, proceeding through phases of activation of quiescent lymphocytes, rapid expansion by cell division and cell differentiation, cessation of division and eventual death of greater than 95 % of the newly generated population. Control of the response is not central but appears to operate as a distributed process where global patterns reliably emerge as a result of collective behaviour of a large number of autonomous cells. In this review, we highlight evidence that competing intracellular timed processes underlie the distribution of individual fates and control cell proliferation, cessation and loss. These principles can be captured in a mathematical model to illustrate consistency with previously published experimentally observed data.
急性适应性免疫反应十分复杂，经历静止淋巴细胞激活、通过细胞分裂和细胞分化快速增殖、分裂停止以及最终超过95%新生成细胞群体死亡的阶段。对该反应的控制并非集中进行，而是似乎作为一个分布式过程运作，在这个过程中，由于大量自主细胞的集体行为，全局模式可靠地出现。在本综述中，我们强调证据表明，相互竞争的细胞内定时过程是个体命运分布的基础，并控制细胞增殖、停止和损失。这些原理可以用一个数学模型来描述，以说明与先前发表的实验观察数据的一致性。
