局部用辛伐他汀对骨再生的作用：一项系统评价。
The role of topical simvastatin on bone regeneration: A systematic review.
作者信息
Montero Javier, Manzano Guillermo, Albaladejo Alberto
机构信息
DDS. PhD, Tenured lecturer in Prosthodontics. Department of Surgery, Faculty of Medicine, University of Salamanca (USAL), Salamanca, Spain.
DDS, Postgraduate Student. Master in Dental Sciences. University of Salamanca (USAL), Salamanca, Spain.
出版信息
J Clin Exp Dent. 2014 Jul 1;6(3):e286-90. doi: 10.4317/jced.51415. eCollection 2014 Jul.
OBJECTIVES
The aim of this systematic review was to summarize the results concerning the use of simvastatin for promoting bone regeneration and to discuss the level of scientific evidence supporting such findings.
MATERIAL AND METHODS
A Pubmed search using "Simvastatin"[Mesh] AND "Bone Regeneration"[Mesh] as Boolean operators was constrained to the last 10 years and only included papers written in English.
RESULTS
Of the 41 relevant papers reviewed, most of them (76.2%) have been published in the last 5 years, and most of them address animal studies (66.6%) performed on rats or rabbits in extraoral regions. Only 4 randomized controlled trials (RCTs) assessed the role of topical simvastatin in periodontal patients.
CONCLUSIONS
A large part of the evidence concerning the role of topical simvastatin on bone regeneration comes from animal studies (mainly rats) focusing on extraoral bone defects. Only the use of subgingival simvastatin after root scaling has been properly supported by RCT. Key words:Simvastatin, bone regeneration, topical administration, osteogenesis, osteoinduction.
目的
本系统评价旨在总结有关使用辛伐他汀促进骨再生的结果，并讨论支持这些发现的科学证据水平。
材料与方法
使用“辛伐他汀”[医学主题词]和“骨再生”[医学主题词]作为布尔运算符在PubMed上进行检索，检索时间限制在过去10年，且仅纳入英文撰写的论文。
结果
在 reviewed 的41篇相关论文中，大多数（76.2%）发表于过去5年，且大多数涉及在口腔外区域对大鼠或兔子进行的动物研究（66.6%）。仅有4项随机对照试验（RCT）评估了局部应用辛伐他汀在牙周病患者中的作用。
结论
关于局部应用辛伐他汀对骨再生作用的大部分证据来自针对口腔外骨缺损的动物研究（主要是大鼠）。只有在根面平整后使用龈下辛伐他汀得到了RCT的适当支持。关键词：辛伐他汀；骨再生；局部给药；成骨；骨诱导
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