Jin Hui, Ji Youbo, Cui Yutao, Xu Li, Liu He, Wang Jincheng
Department of Orthopedics, The Second Hospital of Jilin University, Changchun 130041, P.R. China.
Department of Pain, The Second Hospital of Jilin University, Changchun 130041, P.R. China.
ACS Biomater Sci Eng. 2021 Jun 14;7(6):2177-2191. doi: 10.1021/acsbiomaterials.1c00462. Epub 2021 Apr 20.
Local drug delivery systems composed of biomaterials and osteogenic substances provide promising strategies for the reconstruction of large bone defects. In recent years, simvastatin has been studied extensively for its pleiotropic effects other than lowering of cholesterol, including its ability to induce osteogenesis and angiogenesis. Accordingly, several studies of simvastatin incorporated drug delivery systems have been performed to demonstrate the feasibility of such systems in enhancing bone regeneration. Therefore, this review explores the molecular mechanisms by which simvastatin affects bone metabolism and angiogenesis. The simvastatin concentrations that promote osteogenic differentiation are analyzed. Furthermore, we summarize and discuss a variety of simvastatin-loaded drug delivery systems that use different loading methods and materials. Finally, current shortcomings of and future development directions for simvastatin-loaded drug delivery systems are summarized. This review provides various advanced design strategies for simvastatin-incorporated drug delivery systems that can enhance bone regeneration.
由生物材料和成骨物质组成的局部给药系统为大骨缺损的修复提供了有前景的策略。近年来，辛伐他汀因其除降低胆固醇之外的多种效应而得到广泛研究，包括其诱导成骨和血管生成的能力。因此，已经开展了多项关于含辛伐他汀给药系统的研究，以证明此类系统在促进骨再生方面的可行性。因此，本综述探讨了辛伐他汀影响骨代谢和血管生成的分子机制。分析了促进成骨分化的辛伐他汀浓度。此外，我们总结并讨论了使用不同负载方法和材料的各种载辛伐他汀给药系统。最后，总结了载辛伐他汀给药系统目前的缺点和未来的发展方向。本综述为可促进骨再生的含辛伐他汀给药系统提供了各种先进的设计策略。
