Samieirad Sahand, Labafchi Ali, Famili Khashyar, Hashemzadeh Haleh
Oral and maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Student Research Committee, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
World J Plast Surg. 2021 Jan;10(1):132-135. doi: 10.29252/wjps.10.1.132.
Medication-related osteonecrosis of the jaw (MRONJ) is a serious pathological condition that usually results from anti-resorptive or anti-angiogenic drugs. We aimed to report an unusual MRONJ in a female patient due to long-term simvastatin administration. A 48-year female was referred to the Department of Oral and Maxillofacial, Mashhad Dental School, Mashhad, Iran in Dec 2019. She complained of pain, swelling, and infection in the right mandibular area with a history of extraction. Based on medical history, the patient received 40 mg of simvastatin daily for ten years to control hypercholesterolemia. According to clinical and radiographic examinations, as well as previous medical and dental records, the lesion diagnosis was detected as MRONJ. Moreover, histopathological examination of the lesion confirmed our clinical diagnosis. The necrotic bone was removed with caution. The PRF was then inserted, and the flap was sutured without any tension. No complications were observed on following-up, and all symptoms were discontinued. There was a correlation between the administration of high-dose simvastatin and MRONJ. Moreover, more clinical investigation with larger sample sizes is suggested.
药物相关性颌骨坏死（MRONJ）是一种严重的病理状况，通常由抗吸收或抗血管生成药物引起。我们旨在报告一例因长期服用辛伐他汀导致的不寻常的MRONJ女性患者。一名48岁女性于2019年12月被转诊至伊朗马什哈德马什哈德牙科学院口腔颌面科。她主诉右下颌区域疼痛、肿胀及感染，有拔牙史。根据病史，该患者每日服用40毫克辛伐他汀以控制高胆固醇血症达十年。根据临床和影像学检查以及既往医疗和牙科记录，病变诊断为MRONJ。此外，病变的组织病理学检查证实了我们的临床诊断。小心地清除坏死骨。然后植入富血小板纤维蛋白（PRF），并在无张力情况下缝合皮瓣。随访期间未观察到并发症，所有症状均消失。高剂量辛伐他汀的使用与MRONJ之间存在关联。此外，建议进行更大样本量的更多临床研究。
