Zhu Haitao, Zhu Jinlong, Zhao Tiezhu, Wu Yong, Liu Hongyi, Wu Ting, Yang Lu, Zou Yuanjie, Zhang Rui, Zheng Gang
Department of Neurosurgery, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu 210029, China.
College of Civil Aviation, Nanjing University of Aeronautics and Astronautics, Nanjing, Jiangsu 210016, China.
Biomed Res Int. 2014;2014:171487. doi: 10.1155/2014/171487. Epub 2014 Jul 21.
Resting MEG activities were compared between patients with left temporal lobe epilepsy (LTLE) and normal controls. Using SAMg2, the activities of MEG data were reconstructed and normalized. Significantly elevated SAMg2 signals were found in LTLE patients in the left temporal lobe and medial structures. Marked decreases of SAMg2 signals were found in the wide extratemporal lobe regions, such as the bilateral visual cortex. The study also demonstrated a positive correlation between the seizure frequency and brain activities of the abnormal regions after the multiple linear regression analysis. These results suggested that the aberrant brain activities not only were related to the epileptogenic zones, but also existed in other extratemporal regions in patients with LTLE. The activities of the aberrant regions could be further damaged with the increase of the seizure frequency. Our findings indicated that LTLE could be a multifocal disease, including complex epileptic networks and brain dysfunction networks.
对左侧颞叶癫痫（LTLE）患者和正常对照者的静息态脑磁图（MEG）活动进行了比较。使用SAMg2对MEG数据的活动进行重建和归一化。在LTLE患者的左侧颞叶和内侧结构中发现SAMg2信号显著升高。在广泛的颞叶外区域，如双侧视觉皮层，发现SAMg2信号明显降低。多元线性回归分析后，该研究还表明癫痫发作频率与异常区域的脑活动之间存在正相关。这些结果表明，异常脑活动不仅与致痫区有关，而且在LTLE患者的其他颞叶外区域也存在。随着癫痫发作频率的增加，异常区域的活动可能会进一步受损。我们的研究结果表明，LTLE可能是一种多灶性疾病，包括复杂的癫痫网络和脑功能障碍网络。
