Campbell Matthew, Doyle Sarah, Humphries Peter
The Ocular Genetics Unit, Department of Genetics, Trinity College Dublin, Dublin 2, Ireland.
Expert Rev Clin Immunol. 2014 Oct;10(10):1273-5. doi: 10.1586/1744666X.2014.950231. Epub 2014 Aug 21.
Recent evidence suggests that the pro-inflammatory cytokine IL-18 may have utility as an anti-angiogenic agent in the eye. Numerous laboratories, including our own have demonstrated the ability of murine IL-18 to prevent neovascularization in the retina, choroid and cornea in pathological scenarios. Here, we summarize the potential use of IL-18 as an immunotherapy for wet age-related macular degeneration treatment, describing past and recent findings pertaining to its biological function in the eye.
最近的证据表明，促炎细胞因子白细胞介素-18（IL-18）可能作为眼部抗血管生成剂发挥作用。包括我们自己实验室在内的众多实验室已证明，在病理情况下，小鼠IL-18能够预防视网膜、脉络膜和角膜的新生血管形成。在此，我们总结了IL-18作为湿性年龄相关性黄斑变性治疗免疫疗法的潜在用途，描述了过去和最近关于其在眼部生物学功能的研究发现。
