Pugliese Alberto, Vendrame Francesco, Reijonen Helena, Atkinson Mark A, Campbell-Thompson Martha, Burke George W
Diabetes Research Institute, Miller School of Medicine, University of Miami, 1450 NW 10th Avenue, Miami, FL, 33136, USA,
Curr Diab Rep. 2014 Oct;14(10):530. doi: 10.1007/s11892-014-0530-0.
The Juvenile Diabetes Research Foundation (JDRF) Network for Pancreatic Organ Donors with Diabetes (JDRF nPOD) was established to obtain human pancreata and other tissues from organ donors with type 1 diabetes (T1D) in support of research focused on disease pathogenesis. Since 2007, nPOD has recovered tissues from over 100 T1D donors and distributed specimens to approximately 130 projects led by investigators worldwide. More recently, nPOD established a programmatic expansion that further links the transplantation world to nPOD, nPOD-Transplantation; this effort is pioneering novel approaches to extend the study of islet autoimmunity to the transplanted pancreas and to consent patients for postmortem organ donation directed towards diabetes research. Finally, nPOD actively fosters and coordinates collaborative research among nPOD investigators, with the formation of working groups and the application of team science approaches. Exciting findings are emerging from the collective work of nPOD investigators, which covers multiple aspects of islet autoimmunity and beta cell biology.
青少年糖尿病研究基金会（JDRF）的糖尿病胰腺器官捐赠者网络（JDRF nPOD）旨在从1型糖尿病（T1D）器官捐赠者获取人类胰腺及其他组织，以支持聚焦于疾病发病机制的研究。自2007年以来，nPOD已从100多名T1D捐赠者处获取组织，并将标本分发给全球研究人员主导的约130个项目。最近，nPOD开展了一项计划性扩展，进一步将移植领域与nPOD相连，即nPOD移植项目；这项工作正在开创全新方法，将胰岛自身免疫研究扩展至移植胰腺，并征得患者同意进行针对糖尿病研究的死后器官捐赠。最后，nPOD通过组建工作组并应用团队科学方法，积极促进和协调nPOD研究人员之间的合作研究。nPOD研究人员的集体工作正在产生令人兴奋的发现，其涵盖了胰岛自身免疫和β细胞生物学的多个方面。
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