Gavins Felicity N E, Smith Helen K
Molecular and Cellular Physiology Department, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA.
1] Molecular and Cellular Physiology Department, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA [2] Molecular and Cellular Physiology Department, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA.
J Cereb Blood Flow Metab. 2015 Jul;35(7):1090-9. doi: 10.1038/jcbfm.2015.93. Epub 2015 May 13.
Stem cell therapy has showed considerable potential in the treatment of stroke over the last decade. In order that these therapies may be optimized, the relative benefits of growth factor release, immunomodulation, and direct tissue replacement by therapeutic stem cells are widely under investigation. Fundamental to the progress of this research are effective imaging techniques that enable cell tracking in vivo. Direct analysis of the benefit of cell therapy includes the study of cell migration, localization, division and/or differentiation, and survival. This review explores the various imaging tools currently used in clinics and laboratories, addressing image resolution, long-term cell monitoring, imaging agents/isotopes, as well as safety and costs associated with each technique. Finally, burgeoning tracking techniques are discussed, with emphasis on multimodal imaging.
在过去十年中，干细胞疗法在中风治疗方面已显示出巨大潜力。为了优化这些疗法，治疗性干细胞释放生长因子、免疫调节和直接组织替代的相对益处正在广泛研究中。这项研究进展的基础是有效的成像技术，能够在体内追踪细胞。细胞疗法益处的直接分析包括细胞迁移、定位、分裂和/或分化以及存活的研究。本综述探讨了目前临床和实验室中使用的各种成像工具，涉及图像分辨率、长期细胞监测、成像剂/同位素以及每种技术相关的安全性和成本。最后，讨论了新兴的追踪技术，重点是多模态成像。
