Osawa N, Yamaura N, Ikewaki N, Yashiro K, Akiyama T
Acta Paediatr Jpn. 1989 Aug;31(4):462-8. doi: 10.1111/j.1442-200x.1989.tb01333.x.
In our previous studies, we attempted to show that new-born mice infected with an attenuated strain of Streptococcus pyogenes, and exposed to streptococcal antigens approximately one month later, failed to develop a humoral response to those antigens but were able to respond normally to other unrelated antigens. Since such immunological characteristics are identical to those of patients with the mucocutaneous lymph node syndrome (MCLS), the present studies were performed with the aim of assessing the antibody-forming activities of peripheral blood lymphocytes collected from MCLS patients. These lymphocytes were cultured in the presence of pokeweed mitogen, streptolysin-O and streptococcal C-polysaccharide, leading to their refractoriness to S. pyogenes-associated antigens coupled with normal responsiveness to unrelated antigens. The implication of such immunological responsiveness elicited from neonatal exposure to streptococcal antigens is discussed, particularly with reference to the induction of MCLS.
在我们之前的研究中，我们试图表明，感染了减毒化脓性链球菌菌株的新生小鼠，大约一个月后接触链球菌抗原，对这些抗原未能产生体液反应，但能够对其他不相关抗原正常反应。由于这种免疫特征与皮肤黏膜淋巴结综合征（MCLS）患者的免疫特征相同，本研究旨在评估从MCLS患者采集的外周血淋巴细胞的抗体形成活性。这些淋巴细胞在商陆丝裂原、链球菌溶血素-O和链球菌C多糖存在的情况下培养，导致它们对化脓性链球菌相关抗原产生耐受，而对不相关抗原保持正常反应性。本文讨论了新生儿接触链球菌抗原所引发的这种免疫反应性的意义，特别是关于MCLS的诱发。
