Raymond Michaël, Holtz-Mulholland Michael, Collins Shawn K
Department of Chemistry and Centre for Green Chemistry and Catalysis, Université de Montréal, CP 6128 Station Downtown, Montréal, Québec H3C 3J7 (Canada).
Chemistry. 2014 Sep 26;20(40):12763-7. doi: 10.1002/chem.201404202. Epub 2014 Aug 21.
Macrocyclic olefin metathesis has seen advances in the areas of stereochemistry, chemoselectivity, and catalyst stability, but strategies aimed at controlling dilution effects in macrocyclizations are rare. Herein, a protocol to promote macrocyclic olefin metathesis, one of the most common synthetic tools used to prepare macrocycles, at relatively high concentrations (up to 60 mM) is described by exploitation of a phase-separation strategy. A variety of macrocyclic skeletons could be prepared having either different alkyl, aryl, or amino acids spacers.
大环烯烃复分解反应在立体化学、化学选择性和催化剂稳定性方面取得了进展，但旨在控制大环化中稀释效应的策略却很少见。本文描述了一种通过利用相分离策略，在相对较高浓度（高达60 mM）下促进大环烯烃复分解反应的方法，大环烯烃复分解反应是制备大环化合物最常用的合成工具之一。可以制备具有不同烷基、芳基或氨基酸间隔基的各种大环骨架。
