Discipline of Nutrition, FM&HS, The University of Auckland, Auckland, New Zealand.
Clin Exp Allergy. 2014 Oct;44(10):1255-65. doi: 10.1111/cea.12394.
In a double-blind, randomized, placebo-controlled birth cohort, we have recently shown a beneficial effect of Lactobacillus rhamnosus HN001 (HN001) for the prevention of eczema in children through to 6 years of age but no effect of Bifidobacterium animalis subsp lactis HN019 (HN019).
Among this cohort of children, we aim to investigate whether these probiotics could modify the expression of genetic predisposition to eczema conferred by genetic variation in susceptibility genes.
Thirty-three eczema susceptibility SNPs (in eleven genes) were genotyped in 331 children of European ancestry.
Children who carried a genetic variant that put them at a high risk of developing eczema were less likely to develop eczema if they had been randomized to the HN001 intervention group compared to those in the placebo group. HN019 was also able to protect against the effects of some SNPs. As well as modifying genetic susceptibility to childhood eczema, HN001 was also found to modify genetic susceptibility to eczema severity and atopy risk.
This is the first study to show an effect of a probiotic on reducing eczema risk amongst those with particular eczema-associated genotypes. Our findings suggest that Lactobacillus rhamnosus HN001 may be particularly effective in preventing eczema in children with specific high-risk genotypes.
在一项双盲、随机、安慰剂对照的出生队列研究中，我们最近发现，鼠李糖乳杆菌 HN001（HN001）可通过预防儿童湿疹至 6 岁，从而对湿疹产生有益的影响，但双歧杆菌动物亚种 lactis HN019（HN019）没有这种效果。
在该队列的儿童中，我们旨在调查这些益生菌是否可以改变易患湿疹的遗传易感性基因的遗传变异所赋予的遗传易感性的表达。
在 331 名欧洲血统的儿童中，对 33 个湿疹易感性 SNP（在 11 个基因中）进行了基因分型。
与安慰剂组相比，在随机分配到 HN001 干预组的儿童中，携带易患湿疹的遗传变异体的儿童更不容易患湿疹。HN019 也能够预防一些 SNP 的影响。HN001 不仅可以修饰儿童湿疹的遗传易感性，还可以修饰湿疹严重程度和特应性风险的遗传易感性。
这是第一项研究表明益生菌对降低特定湿疹相关基因型儿童的湿疹风险有影响。我们的研究结果表明，鼠李糖乳杆菌 HN001 可能对预防特定高风险基因型儿童的湿疹特别有效。
