Cheng Jing, Laitila Arja, Ouwehand Arthur C
International Flavors & Fragrances Inc., Global Health and Nutrition Science, Danisco Sweeteners Oy, Kantvik, Finland.
Front Nutr. 2021 Dec 14;8:790561. doi: 10.3389/fnut.2021.790561. eCollection 2021.
Optimal gut motility is central to bowel function and gut health. The link between the gut dysmotility related disorders and dysfunctional-intestinal barriers has led to a hypothesis that certain probiotics could help in normalizing gut motility and maintain gut health. This review investigates the roles of subsp. HN019 ( HN019™) on gut health, and its mechanisms of action in various pre-clinical and clinical studies. Research supports the hypothesis that HN019™ has a beneficial role in maintaining intestinal barrier function during gastrointestinal infections by competing and excluding potential pathogens via different mechanisms; maintaining normal tight junction function and regulating host immune defense toward pathogens in both and human studies. This has been observed to lead to reduced incidence of diarrhea. Interestingly, HN019™ also supports normal physiological function in immunosenescent elderly and competes and excludes potential pathogens. Furthermore, HN019™ reduced intestinal transit time and increased bowel movement frequency in functional constipation, potentially by modulating gut-brain-microbiota axis, mainly via serotonin signaling pathway, through short chain fatty acids derived from microbial fermentation. HN019™ is thus a probiotic that can contribute to relieving gut dysmotility related disorders.
最佳肠道动力是肠道功能和肠道健康的核心。肠道动力障碍相关疾病与肠道屏障功能失调之间的联系引发了一种假说，即某些益生菌可能有助于使肠道动力正常化并维持肠道健康。本综述研究了[具体亚种名称]HN019（HN019™）在肠道健康中的作用及其在各种临床前和临床研究中的作用机制。研究支持这一假说，即HN019™通过不同机制竞争和排除潜在病原体，在胃肠道感染期间对维持肠道屏障功能具有有益作用；在动物和人体研究中维持正常的紧密连接功能并调节宿主对病原体的免疫防御。据观察，这会导致腹泻发病率降低。有趣的是，HN019™还支持免疫衰老老年人的正常生理功能，并竞争和排除潜在病原体。此外，HN019™可能通过调节肠-脑-微生物群轴，主要通过微生物发酵产生的短链脂肪酸，经血清素信号通路，减少功能性便秘患者的肠道转运时间并增加排便频率。因此，HN019™是一种有助于缓解肠道动力障碍相关疾病的益生菌。
