Gomes Clarissa P C, Oliveira Getúlio P, Madrid Bibiano, Almeida Jeeser A, Franco Octávio L, Pereira Rinaldo W
Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília , Brasília, DF , Brazil .
Biomarkers. 2014 Nov;19(7):585-9. doi: 10.3109/1354750X.2014.952663. Epub 2014 Aug 22.
Circulating miRNAs are potential biomarkers that can be important molecules driving cell-to-cell communication.
To investigate circulating muscle-specific miRNAs in recreational athletes.
Three miRNAs from whole plasma before and after a half-marathon were analyzed by qPCR.
MiR-1, -133a, and -206 significantly increased after the race.
Increased levels of miRNAs after exercise point to potential biomarkers and to the possibility of being functional players following endurance training.
These miRNAs are potential biomarkers of muscle damage or adaptation to exercise.
循环中的微小RNA是潜在的生物标志物，可能是驱动细胞间通讯的重要分子。
研究业余运动员循环中的肌肉特异性微小RNA。
采用qPCR分析半程马拉松前后全血中的三种微小RNA。
比赛后miR-1、-133a和-206显著增加。
运动后微小RNA水平升高表明其可能是潜在的生物标志物，也提示其可能是耐力训练后的功能性参与者。
这些微小RNA是肌肉损伤或运动适应性的潜在生物标志物。
