Emmerzaal Tim L, Kiliaan Amanda J, Gustafson Deborah R
Department of Anatomy, Donders Institute for Brain, Cognition and Behaviour, Radboud university medical centre, Nijmegen, The Netherlands.
Department of Neurology, State University of New York-Downstate Medical Center, Brooklyn, NY, USA UMS 011 Inserm Versailles, Saint Quentin, France Institution for Neuroscience and Physiology, Section for Psychiatry and Neurochemistry, University of Gothenburg, Gothenburg, Sweden.
J Alzheimers Dis. 2015;43(3):739-55. doi: 10.3233/JAD-141086.
The occurrence of obesity, commonly estimated using body mass index (BMI), and the most common late-onset dementia, Alzheimer's disease (AD), are increasing globally. The year 2013 marked a decade of epidemiologic observational reports on the association between BMI and late-onset dementias. In this review, we highlight epidemiological studies that measured both mid- and late-life BMI in association with dementia. Studies investigating the association between midlife BMI and risk for dementia demonstrated generally an increased risk among overweight and obese adults. When measured in late-life, elevated BMI has been associated with lower risk. In addition, being underweight and/or having a decrease in BMI in late-life are associated with higher dementia risk compared to BMI in the normal range or stable BMI. In this review, a decade (2003-2013) of epidemiologic observational studies on associations between BMI and AD is highlighted. These observations provide a strong base for addressing biological mechanisms underlying this complex association.
肥胖的发生率通常使用体重指数（BMI）来估算，而最常见的晚发性痴呆症——阿尔茨海默病（AD）——在全球范围内都呈上升趋势。2013年标志着关于BMI与晚发性痴呆症之间关联的十年流行病学观察报告。在本综述中，我们重点介绍了那些测量中年和晚年BMI与痴呆症之间关联的流行病学研究。调查中年BMI与痴呆症风险之间关联的研究普遍表明，超重和肥胖成年人的风险增加。在晚年进行测量时，BMI升高与较低风险相关。此外，与正常范围的BMI或稳定的BMI相比，晚年体重过轻和/或BMI下降与更高的痴呆症风险相关。在本综述中，重点介绍了十年（2003 - 2013年）关于BMI与AD之间关联的流行病学观察研究。这些观察结果为探讨这种复杂关联背后的生物学机制提供了坚实的基础。
