Lugo-Villarino Geanncarlo, Neyrolles Olivier
Centre National de la Recherche Scientifique (CNRS), Institut de Pharmacologie et de Biologie Structurale (IPBS), 31000 Toulouse, France Université de Toulouse, Université Paul Sabatier, Institut de Pharmacologie et de Biologie Structurale (IPBS), 31000 Toulouse, France.
Cold Spring Harb Perspect Med. 2014 Aug 21;4(11):a018549. doi: 10.1101/cshperspect.a018549.
Over the past 20 years, there has been an emerging appreciation about the role of the mononuclear phagocyte system (MPS) to control and eradicate pathogens. Likewise, there have been significant advances in dissecting the mechanisms involved in the microbial subversion of MPS cells, mainly affecting their differentiation and effector functions. Mycobacterium tuberculosis is a chronic bacterial pathogen that represents an enigma to the field because of its remarkable ability to thrive in humans. One reason is that M. tuberculosis renders a defective MPS compartment, which is perhaps the most ingenious strategy for survival in the host given the prominence of these cells to modulate microenvironments, their function as sentinels and orchestrators of the immune response, and their pathogenic role as reservoirs for microbial persistence. In this article, the principal strategies used by M. tuberculosis to subvert the MPS compartment are presented along with emerging concepts.
在过去20年里，人们逐渐认识到单核吞噬细胞系统（MPS）在控制和根除病原体方面的作用。同样，在剖析微生物颠覆MPS细胞所涉及的机制方面也取得了重大进展，这些机制主要影响MPS细胞的分化和效应功能。结核分枝杆菌是一种慢性细菌病原体，因其在人类体内显著的生存能力，成为该领域的一个谜。原因之一是结核分枝杆菌使MPS区室功能缺陷，鉴于这些细胞在调节微环境、作为免疫反应的哨兵和协调者的功能以及作为微生物持续存在的储存库的致病作用，这可能是其在宿主体内生存的最巧妙策略。本文介绍了结核分枝杆菌颠覆MPS区室所采用的主要策略以及一些新出现的概念。
