Cardiovascular Research Institute, University of California-San Francisco, CA 94158-9001, USA.
Immunity. 2013 Apr 18;38(4):644-54. doi: 10.1016/j.immuni.2013.04.001.
Mammals possess a remarkable ability to maintain and defend a constant internal milieu against diverse environmental threats. Unsurprisingly, the two systems tasked with these duties, metabolism and immunity, have evolved to share a common modular architecture that allows extensive bidirectional communication and coordination. Indeed, recent observations have highlighted numerous functionally critical immune regulatory modules located within diverse metabolic circuits. In this review, we discuss the architectural commonality between immunity and metabolism and highlight how these two primordially disparate systems leverage shared regulatory axes to coordinate metabolic physiology under conditions of normality and chronic overnutrition. Such an integrated perspective both advances our understanding of basic physiology and highlights potential opportunities for therapeutic intervention in metabolic dysfunction.
哺乳动物具有维持和保护内部环境稳定的卓越能力，以抵御各种环境威胁。毫不奇怪，负责这项任务的两个系统——代谢和免疫——已经进化出共同的模块化架构，允许广泛的双向交流和协调。事实上，最近的观察结果强调了许多位于不同代谢回路中的具有重要功能的免疫调节模块。在这篇综述中，我们讨论了免疫和代谢之间的结构共性，并强调了这两个最初截然不同的系统如何利用共享的调节轴在正常和慢性营养过剩的情况下协调代谢生理学。这种综合观点不仅增进了我们对基本生理学的理解，还突出了在代谢功能障碍的治疗干预方面的潜在机会。
