Wetzler Meir
ROSWELL PARK CANCER INSTITUTE.
Blood. 2014 Aug 21;124(8):1206-7. doi: 10.1182/blood-2014-07-585919.
In this issue of , Fernandez et al demonstrate that human leukocyte antigen () alleles confer high-affinity binding to asparaginase epitopes, leading to higher frequency of allergic reactions. The authors initially examined data from European ancestry patients enrolled onto St. Jude Children’s Research Hospital (n = 541) and the Children’s Oncology Group (n = 1329) clinical trials and identified a higher incidence of allergic reactions and anti-asparaginase antibodies in patients with alleles. They then analyzed the structure of the HLA protein to show high-risk amino acids located within the binding pocket (see figure), possibly affecting the interaction between asparaginase epitopes and the HLA-DRB1 protein.
在本期杂志中，费尔南德斯等人证明人类白细胞抗原（）等位基因与天冬酰胺酶表位具有高亲和力结合，导致过敏反应的发生率更高。作者最初检查了参与圣裘德儿童研究医院（n = 541）和儿童肿瘤学组（n = 1329）临床试验的欧洲血统患者的数据，并确定携带等位基因的患者中过敏反应和抗天冬酰胺酶抗体的发生率更高。然后，他们分析了HLA蛋白的结构，以显示位于结合口袋内的高风险氨基酸（见图），这可能会影响天冬酰胺酶表位与HLA - DRB1蛋白之间的相互作用。
