Lee Seung Ku, Yoon Dae Wui, Yi Hyeryeon, Lee Si Woo, Kim Jong Yeol, Kim Jin Kwan, Hong Jeong Hwa, Shin Chol
1 Institute of Human Genomic Study, College of Medicine, Korea University Ansan Hospital , Ansan, Republic of Korea.
J Altern Complement Med. 2014 Nov;20(11):846-52. doi: 10.1089/acm.2014.0077. Epub 2014 Aug 22.
It has been hypothesized that Sasang constitutional types (SCTs) have a specific hypoactive organ, which can account for vulnerability to related diseases or symptoms. This study examined the relationship between SCTs and irritable bowel syndrome (IBS).
Cross-sectional study in a population-based cohort study in Korea.
1362 individuals (705 men and 657 women) who participated in the Korean Genome and Epidemiology Study.
The participants were classified into SCTs by the integrated diagnostic model and asked about symptoms related to IBS using the Rome II criteria.
The prevalence of IBS differed significantly among the SCTs, with 33 (18.3%) of the So-eum (SE) type, 74 (9.9%) of the Tae-eum (TE) type, and 57 (13.2%) of the So-yang (SY) type having IBS. Even after adjustment for possible confounders, the SE type for both sexes continued to show 1.82-fold (95% confidence interval [CI], 1.05-3.16) excess odds of having IBS. Men with SE type had a 2.97 times (95% CI, 1.34-6.58) and a 2.50 times (95% CI, 1.15-5.47) significantly higher odds of having IBS than the TE and SY types, respectively. In analysis for the joint effect of SCT and psychological stress, the multivariate odds ratio of IBS was 3.21 (95% CI, 1.33-7.75) for the SE type and Psychological Well-Being Index-Short Form (PWI-SF) score (<27), and 5.83 (95% CI, 1.80-18.88) for the SE type and PWI-SF (≥27) compared with the TE type and PWI-SF score (<27).
The SE type of SCT is an independent risk factor for IBS. The findings support the hypothesis that persons with SE type are vulnerable to gastrointestinal diseases.
有假说认为，体质类型（SCTs）存在特定的机能减退器官，这可以解释对相关疾病或症状的易感性。本研究探讨了体质类型与肠易激综合征（IBS）之间的关系。
在韩国一项基于人群的队列研究中进行的横断面研究。
1362名个体（705名男性和657名女性）参与了韩国基因组与流行病学研究。
采用综合诊断模型将参与者分为不同的体质类型，并使用罗马II标准询问与IBS相关的症状。
不同体质类型中IBS的患病率存在显著差异，少阴（SE）型中有33人（18.3%）患IBS，太阴（TE）型中有74人（9.9%）患IBS，少阳（SY）型中有57人（13.2%）患IBS。即使对可能的混杂因素进行调整后，两性的少阴型患IBS的优势比仍持续显示高出1.82倍（95%置信区间[CI]，1.05 - 3.16）。少阴型男性患IBS的几率分别比太阴型和少阳型高2.97倍（95% CI，1.34 - 6.58）和2.50倍（95% CI，1.15 - 5.47）。在分析体质类型和心理压力的联合效应时，与太阴型和心理健康指数简表（PWI - SF）得分（<27）相比，少阴型且PWI - SF得分（<27）的IBS多变量优势比为3.21（95% CI，1.33 - 7.75），少阴型且PWI - SF（≥27）的多变量优势比为5.83（95% CI，1.80 - 18.88）。
少阴型体质类型是IBS的独立危险因素。这些发现支持了少阴型体质者易患胃肠道疾病这一假说。
