Lee Seung Ku, Yoon Dae Wui, Lee Si Woo, Kim Jong Yeol, Kim Jin Kwan, Shin Chol
Institute of Human Genomic Study, College of Medicine, Korea University Ansan Hospital, 516 Gojan-1-dong, Danwon-gu, Gyeonggi-do, Ansan, 425-707, Republic of Korea.
Constitutional Medicine and Diagnosis Research Group, Korea Institute of Oriental Medicine, 461-24 Jeonmin-dong, Yuseong-gu, Daejeon, 305-811, Republic of Korea.
BMC Complement Altern Med. 2015 Nov 7;15:399. doi: 10.1186/s12906-015-0925-8.
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and is highly prevalent in populations with metabolic conditions such as obesity and type II diabetes. Specific types of Sasang constitution can act as a risk factor for metabolic diseases, but there are no studies addressing the association between the Sasang constitutional types (SCTs) and NAFLD.
A total of 1184 individuals (508 males, 676 females) that enrolled in the Korean Genome and Epidemiology Study were included in the present study. Classification of SCTs was done with an integrated diagnostic model. NAFLD was diagnosed when the liver attenuation index (LAI) value was <5 Hounsfield units using computed tomography. Relationships between the SCTs and NAFLD were analyzed using multiple logistic regressions.
The average LAI was 13.3±6.0 in the So-eum (SE) type, 12.3±7.0 in the So-yang (SY) type, and 6.5±9.9 in the Tae-eum (TE) type. Prevalence of NAFLD was 4.7% in the SE type, 14.0% in the SY type, and 34% in the TE type. Even after adjusting for possible confounders, the SY and TE types continued to show a 3.90-fold (95% CI, 1.60-9.51; P=0.0028) and 3.36-fold (95% CI, 1.42-7.92; P=0.0057) increase in chance of having NAFLD, respectively, compared with the SE type. In the additional analysis including only non-obese subjects, the odds ratio of NAFLD was 3.27 (95% CI, 1.29-8.29; P=0.0126) in the SY type and 3.53 (95% CI, 1.30-9.58; P=0.0134) in the TE type compared with SE type. In the multivariate analysis to determine which parameter had an independent association with NAFLD, higher body mass index, alanine aminotransferase (ALT), triglyceride (TG), and low high-density lipoprotein cholesterol were independently associated with developing NAFLD in the SY type. In contrast, male sex, alcohol consumption, higher ALT, TG, and fasting glucose were risk factors for NAFLD in the TE type.
These results indicated that the SY and TE types are independent risk factors for NAFLD.
非酒精性脂肪性肝病（NAFLD）是慢性肝病最常见的病因，在肥胖和II型糖尿病等代谢性疾病人群中高度流行。特定类型的体质可作为代谢性疾病的危险因素，但尚无关于体质类型（SCTs）与NAFLD之间关联的研究。
本研究纳入了韩国基因组与流行病学研究中的1184名个体（508名男性，676名女性）。采用综合诊断模型进行SCTs分类。当肝脏衰减指数（LAI）值<5亨氏单位时，通过计算机断层扫描诊断为NAFLD。使用多元逻辑回归分析SCTs与NAFLD之间的关系。
少阴（SE）型的平均LAI为13.3±6.0，少阳（SY）型为12.3±7.0，太阴（TE）型为6.5±9.9。SE型NAFLD患病率为4.7%，SY型为14.0%，TE型为34%。即使在调整了可能的混杂因素后，与SE型相比，SY型和TE型患NAFLD的几率仍分别增加3.90倍（95%CI，1.60 - 9.51；P = 0.0028）和3.36倍（95%CI，1.42 - 7.92；P = 0.0057）。在仅包括非肥胖受试者的额外分析中，与SE型相比，SY型NAFLD的优势比为3.27（95%CI，1.29 - 8.29；P = 0.0126），TE型为3.53（95%CI，1.30 - 9.58；P = 0.0134）。在确定哪些参数与NAFLD有独立关联的多变量分析中，较高的体重指数、丙氨酸氨基转移酶（ALT）、甘油三酯（TG）和低高密度脂蛋白胆固醇与SY型发生NAFLD独立相关。相比之下，男性、饮酒、较高的ALT、TG和空腹血糖是TE型NAFLD的危险因素。
这些结果表明，SY型和TE型是NAFLD的独立危险因素。
