Department of Pharmacology and clinical Pharmacy, School of Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia.
BMC Complement Altern Med. 2014 Aug 23;14:310. doi: 10.1186/1472-6882-14-310.
Foeniculum vulgare locally known as ensilal, is an aromatic plant widely cultivated in temperate and tropical regions. The anti-anxiety activity of the crude extract of F. vulgare has been reported. However, the fraction responsible for anxiolytic activity is not known and there is no any report on the anti-anxiety activity of the essential oil of F. vulgare. The objective of study was to evaluate the anxiolytic activity of the essential oil of Foeniculum vulgare Miller.
Adult Swiss albino male mice were randomly divided into six groups (n = 6). Groups I and II received Tween 80 (5%, v/v) and diazepam (0.5 mg/kg, ip), respectively, while groups III to V received orally 50, 100, and 200 and 400 mg/kg doses of the essential oil of F. vulgare, respectively. The mice were then individually placed in animal anxiety models: elevated plus maze (EPM), staircase test (SCT) and open field test (OFT) and evaluated for various parameters.
In EPM test, 100 and 200 mg/kg doses of the essential oil significantly increased percent number of entries and time spent in open arms compared to control. In SCT these doses also reduced rearing significantly compared to controls, while only the 200 mg/kg dose significantly increased number of squares crossed at the center in the OFT test.
The essential oil of F. vulgare was found to exhibit a promising anxiolytic activity.
茴香，俗称 ensilal，是一种广泛种植于温带和热带地区的芳香植物。已报道茴香粗提取物具有抗焦虑活性。然而，负责抗焦虑活性的馏分尚不清楚，也没有关于茴香精油抗焦虑活性的报道。本研究的目的是评估茴香精油的抗焦虑活性。
成年瑞士白化雄性小鼠随机分为六组（n = 6）。第 I 组和第 II 组分别给予吐温 80（5%，v/v）和地西泮（0.5 mg/kg，ip），第 III 组至第 V 组分别给予 50、100、200 和 400 mg/kg 剂量的茴香精油。然后将小鼠分别放入动物焦虑模型：高架十字迷宫（EPM）、阶梯测试（SCT）和旷场测试（OFT）中，并评估各种参数。
在 EPM 测试中，100 和 200 mg/kg 剂量的精油与对照组相比，显著增加了进入开放臂的百分比和在开放臂中花费的时间。在 SCT 中，这些剂量还显著减少了与对照组相比的直立次数，而只有 200 mg/kg 剂量在 OFT 测试中显著增加了中心交叉的方格数。
茴香精油具有有希望的抗焦虑活性。
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