Abbas Afshan, Ikram Rahila, Khan Saira Saeed, Ahmed Shadab, Osama Muhammad
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.
Pak J Pharm Sci. 2019 Jul;32(4(Supplementary)):1813-1819.
This novel study was conducted with objective to evaluate the anxiolytic potential of whole-crushed seeds of Foeniculum vulgare (FV) which were incorporated in diet. Albino mice were divided in three groups: Control-group, Study-group 2% FV and Study-group 4% FV, each having 10 mice. Special dietary pellets containing whole-crushed Foeniculum vulgare seeds were prepared in 2% and 4% ratio, respectively and were fed to respective Study groups whereas Control-group was given regular rodent diet for 2 months. Animal behaviour was assessed using Home Cage Activity test, Head Dip test, Light and Dark Box test and Open Field test at intervals of 15 days for a period of 2 months. The results of this study showed, decrease in Cage Crossing activity, more number of Head Dips, increased time spent in Light box and increase in number of transitions between Light and Dark Box, increased number of Central Squares Crossed and increased time spent in Central Squares of Open Field arena for both study groups in comparison with control group. Foeniculum vulgare whole-crushed seeds diet of 2% and 4% was found to have anxiolytic effect.
这项新研究旨在评估添加到饮食中的小茴香全碎种子的抗焦虑潜力。将白化小鼠分为三组：对照组、2%小茴香研究组和4%小茴香研究组，每组10只小鼠。分别以2%和4%的比例制备了含有小茴香全碎种子的特殊饮食颗粒，并喂给相应的研究组，而对照组则喂食常规啮齿动物饮食，持续2个月。在2个月的时间里，每隔15天使用笼内活动测试、头部浸入测试、明暗箱测试和旷场测试对动物行为进行评估。这项研究的结果表明，与对照组相比，两个研究组的笼内穿越活动减少、头部浸入次数增加、在明箱中花费的时间增加、明暗箱之间的转换次数增加、穿越中央方格的次数增加以及在旷场区域中央方格中花费的时间增加。发现2%和4%的小茴香全碎种子饮食具有抗焦虑作用。
