Vernay D, Eschalier A, Durif F, Aumaitre O, Rigal B, Ben Sadoun A, Fialip J, Marty H, Philip E, Bougerolle A M
Service de Neurologie, Hôpital Nord, Clermont-Ferrand.
Encephale. 1989 Nov-Dec;15(6):511-6.
Salsolinol can be formed either by condensation of dopamine with acetaldehyde, or by condensation of dopamine with pyruvic acid followed by decarboxylation. Salsolinol has a complex pharmacologic profile. Its opium-like activity may be related to alcohol dependency and to the effectiveness of naloxone during acute alcohol intoxication. Because they had noticed that alcoholism and Parkinson's disease rarely coexist, the authors undertook a study to confirm this fact and attempt to explain it by implicating salsolinol. Urinary excretion of salsolinol was found to increase following ingestion of alcohol, as well as in Parkinson patients under L-dopa treatment. The authors also found that urinary salsolinol was very low in untreated patients with Parkinson's disease. Salsolinol was detected in a number of foods and beverages. Separate assays of enantiomeres showed that the S enantiomere predominates in some foods whereas the R enantiomere is more abundant in humans. Lastly, the antinociceptive effects of salsolinol and its enantiomeres were studied in mice and antidepressant effects were evidenced using predictive tests.
猪毛菜酚可通过多巴胺与乙醛缩合形成，也可通过多巴胺与丙酮酸缩合，然后脱羧形成。猪毛菜酚具有复杂的药理特性。其类似鸦片的活性可能与酒精依赖以及纳洛酮在急性酒精中毒期间的有效性有关。由于他们注意到酒精中毒和帕金森病很少同时存在，作者进行了一项研究以证实这一事实，并试图通过涉及猪毛菜酚来解释它。发现摄入酒精后以及接受左旋多巴治疗的帕金森病患者中，猪毛菜酚的尿排泄量会增加。作者还发现，未经治疗的帕金森病患者尿中的猪毛菜酚含量非常低。在许多食物和饮料中都检测到了猪毛菜酚。对映体的单独测定表明，S对映体在某些食物中占主导地位，而R对映体在人体中更为丰富。最后，在小鼠中研究了猪毛菜酚及其对映体的抗伤害感受作用，并使用预测性试验证明了其抗抑郁作用。
