Clow A, Topham A, Saunders J B, Murray R, Sandler M
Prog Clin Biol Res. 1985;183:101-13.
We studied the urinary excretion of the tetrahydroisoquinoline (TIQ) salsolinol, formed from acetaldehyde and dopamine, in both severely and moderately dependent alcoholics during withdrawal from alcohol and subsequent challenge with an acute dose of alcohol and L-dopa, and compared these results with controls. Plasma acetaldehyde and alcohol levels in a sub-population of severely dependent withdrawn alcoholic and control subjects following an acute dose of alcohol were also determined. Salsolinol excretion during the first 4 days of alcohol withdrawal was variable but 10 out of 14 alcoholics showed an increasing trend from day 1 to day 3 and 4 of alcohol withdrawal. L-dopa administration raised salsolinol excretion in controls and withdrawn alcoholics to a uniform extent. Loading of the withdrawn alcoholics with an acute dose of alcohol did not cause an increase in urinary salsolinol concentration (despite increased plasma acetaldehyde). Indeed, 24 h following acute alcohol administration, salsolinol excretion rates were depressed in the alcoholics but not in the controls.
我们研究了由乙醛和多巴胺生成的四氢异喹啉（TIQ）索索林醇在重度和中度酒精依赖者戒酒期间以及随后给予急性剂量酒精和左旋多巴激发后的尿排泄情况，并将这些结果与对照组进行了比较。还测定了一组重度酒精依赖戒断的酗酒者和对照受试者在给予急性剂量酒精后的血浆乙醛和酒精水平。戒酒的前4天，索索林醇排泄情况各异，但14名酗酒者中有10名从戒酒第1天到第3天和第4天呈上升趋势。给予左旋多巴使对照组和戒断酗酒者的索索林醇排泄均有同等程度增加。给予急性剂量酒精使戒断酗酒者负荷增加，但未导致尿索索林醇浓度升高（尽管血浆乙醛增加）。实际上，急性酒精给药24小时后，酗酒者的索索林醇排泄率降低，而对照组未降低。
