Steiger A, Benkert O, Wöhrmann S, Steinseifer D, Holsboer F
Department of Psychiatry, University of Mainz, FRG.
Neuropsychobiology. 1989;21(2):71-5. doi: 10.1159/000118555.
Sleep EEG, nocturnal penile tumescence (NPT) and nocturnal endocrine activity were studied in 3 male control subjects during placebo, under trimipramine (TR) and after withdrawal. TR did not change the sleep structure. NPT activity tended to increase under TR. Nocturnal plasma cortisol levels decreased markedly while the early morning rise of cortisol appeared delayed under 200 mg TR. After withdrawal the changes of the cortisol secretion rebounded. Nocturnal secretion of GH, testosterone, LH and FSH remained unaffected, but plasma prolactin levels increased under TR and returned to normalcy after cessation. Our data illustrate that the neurobiological effects of TR are different from those of other antidepressants. We suggest that some of the psychotropic effects of TR are mediated by suppression of cortisol.
在3名男性对照受试者中，研究了安慰剂、曲米帕明（TR）治疗期间及撤药后睡眠脑电图、夜间阴茎勃起（NPT）和夜间内分泌活动。TR未改变睡眠结构。NPT活动在TR治疗下有增加趋势。夜间血浆皮质醇水平显著降低，而在200mg TR治疗下，皮质醇清晨升高出现延迟。撤药后，皮质醇分泌的变化出现反弹。生长激素、睾酮、促黄体生成素和促卵泡生成素的夜间分泌未受影响，但血浆催乳素水平在TR治疗下升高，停药后恢复正常。我们的数据表明，TR的神经生物学效应与其他抗抑郁药不同。我们认为，TR的一些精神otropic作用是由皮质醇抑制介导的。
