von Bardeleben U, Steiger A, Gerken A, Holsboer F
Department of Psychiatry, University of Freiburg, Federal Republic of Germany.
Int Clin Psychopharmacol. 1989 Jan;4 Suppl 1:1-5.
A single dose of 80 mg fluoxetine induced a slight increase in cortisol secretion when compared to placebo in an acute endocrine challenge test including assessment of prolactin, growth hormone, luteinizing hormone, follicle stimulating hormone, testosterone. This pretreatment with 80 mg fluoxetine did not change the ACTH release after blockade of the feed-back regulation of peripheral corticosteroids on ACTH secretion by metyrapone. Sleep-EEG revealed reduction of rapid-eye-movement sleep. Nocturnal penile tumescence activity was unaltered.
在一项包括对催乳素、生长激素、促黄体生成素、促卵泡激素、睾酮进行评估的急性内分泌激发试验中，与安慰剂相比，单次服用80毫克氟西汀会导致皮质醇分泌略有增加。在使用美替拉酮阻断外周皮质类固醇对促肾上腺皮质激素（ACTH）分泌的反馈调节后，80毫克氟西汀的这种预处理并未改变ACTH的释放。睡眠脑电图显示快速眼动睡眠减少。夜间阴茎勃起功能未改变。
