Steiger A, Benkert O, Holsboer F
Department of Psychiatry, University of Mainz, Germany.
Neuropsychobiology. 1994;30(2-3):101-5. doi: 10.1159/000119145.
Sleep EEG, nocturnal penile tumescence (NPT) and nocturnal hormone secretion were studied in four normal males during placebo, under up to 300 mg per day of moclobemide, the short-acting and reversible inhibitor of monoamine oxidase (type A), and after withdrawal. Under moclobemide, REM sleep was slightly suppressed. Drug cessation was followed by REM rebound. In contrast to REM sleep, NPT was not affected by the drug. The nocturnal cortisol concentration was elevated under moclobemide and this effect persisted after withdrawal. No influences on growth hormone, prolactin, testosterone, luteinizing hormone or follicle-stimulating hormone were found.
对4名正常男性在服用安慰剂期间、服用高达每天300毫克吗氯贝胺（一种短效且可逆的A型单胺氧化酶抑制剂）期间以及停药后，进行了睡眠脑电图、夜间阴茎勃起（NPT）和夜间激素分泌的研究。在服用吗氯贝胺的情况下，快速眼动睡眠（REM睡眠）略有抑制。停药后出现REM睡眠反弹。与REM睡眠相反，NPT不受该药物影响。服用吗氯贝胺期间夜间皮质醇浓度升高，停药后这种效应仍持续存在。未发现对生长激素、催乳素、睾酮、促黄体生成素或促卵泡激素有影响。
