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本文引用的文献

1
Second generation snake antivenomics: comparing immunoaffinity and immunodepletion protocols.第二代蛇类抗蛇毒血清组学：免疫亲和与免疫耗竭方案比较。
Toxicon. 2012 Sep 15;60(4):688-99. doi: 10.1016/j.toxicon.2012.04.342. Epub 2012 Apr 26.
2
Comparative proteomic analysis of the venom of the taipan snake, Oxyuranus scutellatus, from Papua New Guinea and Australia: role of neurotoxic and procoagulant effects in venom toxicity.比较巴布亚新几内亚和澳大利亚的太攀蛇（Oxyuranus scutellatus）毒液的蛋白质组学分析：神经毒性和促凝血作用在毒液毒性中的作用。
J Proteomics. 2012 Apr 3;75(7):2128-40. doi: 10.1016/j.jprot.2012.01.006. Epub 2012 Jan 14.
3
Proteomic tools against the neglected pathology of snake bite envenoming.针对被忽视的蛇咬伤病理的蛋白质组学工具。
Expert Rev Proteomics. 2011 Dec;8(6):739-58. doi: 10.1586/epr.11.61.
4
Ending the drought: new strategies for improving the flow of affordable, effective antivenoms in Asia and Africa.终结干旱：改善亚洲和非洲负担得起的、有效的抗蛇毒血清供应的新策略。
J Proteomics. 2011 Aug 24;74(9):1735-67. doi: 10.1016/j.jprot.2011.05.027. Epub 2011 May 19.
5
Preclinical evaluation of caprylic acid-fractionated IgG antivenom for the treatment of Taipan (Oxyuranus scutellatus) envenoming in Papua New Guinea.用于治疗巴布亚新几内亚太攀蛇（Oxyuranus scutellatus）咬伤的辛酸分级 IgG 抗蛇毒血清的临床前评估。
PLoS Negl Trop Dis. 2011 May;5(5):e1144. doi: 10.1371/journal.pntd.0001144. Epub 2011 May 17.
6
Antivenomic assessment of the immunological reactivity of EchiTAb-Plus-ICP, an antivenom for the treatment of snakebite envenoming in sub-Saharan Africa.抗蛇毒血清 EchiTAb-Plus-ICP 的免疫反应性的抗毒液组学评估，该抗蛇毒血清用于治疗撒哈拉以南非洲的蛇咬伤中毒。
Am J Trop Med Hyg. 2010 Jun;82(6):1194-201. doi: 10.4269/ajtmh.2010.09-0733.
7
Commercial monovalent antivenoms in Australia are polyvalent.澳大利亚的商业单价抗蛇毒血清实际上是多价的。
Toxicon. 2009 Aug;54(2):192-5. doi: 10.1016/j.toxicon.2009.04.004. Epub 2009 Apr 16.
8
Snake venomics and antivenomics: Proteomic tools in the design and control of antivenoms for the treatment of snakebite envenoming.蛇毒组学与抗蛇毒血清组学：用于设计和控制治疗蛇咬伤中毒抗蛇毒血清的蛋白质组学工具。
J Proteomics. 2009 Mar 6;72(2):165-82. doi: 10.1016/j.jprot.2009.01.008. Epub 2009 Jan 21.
9
Snake venomics and antivenomics of the arboreal neotropical pitvipers Bothriechis lateralis and Bothriechis schlegelii.树栖新热带蝰蛇侧带棕榈蝰和施氏棕榈蝰的蛇毒组学与抗蛇毒组学
J Proteome Res. 2008 Jun;7(6):2445-57. doi: 10.1021/pr8000139. Epub 2008 Apr 30.
10
Isolation and pharmacological characterization of cannitoxin, a presynaptic neurotoxin from the venom of the Papuan Taipan (Oxyuranus scutellatus canni).巴布亚太攀蛇（Oxyuranus scutellatus canni）毒液中一种突触前神经毒素——卡尼毒素的分离与药理学特性研究
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对来自巴布亚新几内亚和澳大利亚的针对太攀蛇（盾鳞棘背蛇，Oxyuranus scutellatus）毒液的两种抗蛇毒血清进行抗蛇毒血清组学特征分析。

Antivenomic characterization of two antivenoms against the venom of the taipan, Oxyuranus scutellatus, from Papua New Guinea and Australia.

作者信息

Herrera María, Paiva Owen K, Pagotto Ana Helena, Segura Alvaro, Serrano Solange M T, Vargas Mariángela, Villalta Mauren, Jensen Simon D, León Guillermo, Williams David J, Gutiérrez José María

机构信息

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica; Charles Campbell Toxinology Centre, School of Medicine and Health Sciences, University of Papua New Guinea, Port Moresby, Papua New Guinea; Special Laboratory of Applied Toxinology, Center of Toxins, Immune-Response and Cell Signaling (CeTICS), Instituto Butantan, Sao Paulo, Brazil; Australian Venom Research Unit, Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria, Australia.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica; Charles Campbell Toxinology Centre, School of Medicine and Health Sciences, University of Papua New Guinea, Port Moresby, Papua New Guinea; Special Laboratory of Applied Toxinology, Center of Toxins, Immune-Response and Cell Signaling (CeTICS), Instituto Butantan, Sao Paulo, Brazil; Australian Venom Research Unit, Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria, Australia

出版信息

Am J Trop Med Hyg. 2014 Nov;91(5):887-94. doi: 10.4269/ajtmh.14-0333. Epub 2014 Aug 25.

DOI:10.4269/ajtmh.14-0333
PMID:25157124
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4228881/
Abstract

Antivenoms manufactured by bioCSL Limited (Australia) and Instituto Clodomiro Picado (Costa Rica) against the venom of the taipan snakes (Oxyuranus scutellatus) from Australia and Papua New Guinea (PNG), respectively, were compared using antivenomics, an analytical approach that combines proteomics with immunoaffinity chromatography. Both antivenoms recognized all venom proteins present in venom from PNG O. scutellatus, although a pattern of partial recognition was observed for some components. In the case of the Australian O. scutellatus venom, both antivenoms immunorecognized the majority of the components, but the CSL antivenom showed a stronger pattern of immunoreactivity, which was revealed by the percentage of retained proteins in the immunoaffinity column. Antivenoms interacted with taipoxin in surface plasmon resonance. These observations on antivenomics agree with previous neutralization studies.

摘要

采用抗蛇毒血清组学（一种将蛋白质组学与免疫亲和色谱相结合的分析方法），对澳大利亚生物CSL有限公司和哥斯达黎加克洛多米罗·皮卡多研究所分别生产的针对澳大利亚和巴布亚新几内亚太攀蛇（盾鳞棘背蛇）毒液的抗蛇毒血清进行了比较。两种抗蛇毒血清都能识别巴布亚新几内亚盾鳞棘背蛇毒液中存在的所有毒液蛋白，不过对某些成分观察到了部分识别模式。对于澳大利亚盾鳞棘背蛇毒液，两种抗蛇毒血清都能免疫识别大多数成分，但CSL抗蛇毒血清显示出更强的免疫反应模式，这通过免疫亲和柱中保留蛋白质的百分比得以揭示。抗蛇毒血清在表面等离子体共振中与太攀毒素相互作用。这些关于抗蛇毒血清组学的观察结果与先前的中和研究一致。