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黑色素瘤:一种降低发病率和死亡率的新策略。

Melanoma: A new strategy to reduce morbidity and mortality.

作者信息

Williams Cameron, Quirk Christopher, Quirk Anna

机构信息

Austin Hospital, Melbourne, Australia.

出版信息

Australas Med J. 2014 Jul 31;7(7):266-71. doi: 10.4066/AMJ.2014.1949. eCollection 2014.

Abstract

BACKGROUND

Public awareness campaigns could address risk factors for melanoma to reinforce their sun protection message. The objective of this study is to prioritise risk factors associated with malignant melanoma (MM) to improve public awareness.

DESIGN

A cross-sectional study with retrospective data analysis from 2004 to 2010.

SETTING

Western Australian Melanoma Advisory Service (WAMAS), a tertiary referral multidisciplinary organisation providing MM management advice. WAMAS data files were analysed with histologically confirmed cutaneous MM. Forty- seven patients had two or more melanomas, but the patient file was counted only once. Six MM data files with missing or incomplete information were excluded.

MAIN OUTCOME MEASURES

The number of naevi, blood relatives with MM, and previous sunburns were the primary variables collected.

RESULTS

The results showed that 70.9 per cent (268/378) had previous sunburn; 40.2 per cent (152/378) had multiple naevi; and 22.5 per cent (85/378) had a positive family history. In the 110 MM data files not associated with sunburn, multiple naevi and a positive family history represented 34.5 per cent (38/110) and 20.0 per cent (22/110), respectively.

CONCLUSION

The results confirm the findings of previous studies that multiple naevi and a positive family history are important risk factors associated with MM. We suggest that MM can be detected earlier and its mortality decreased by focusing on these high-risk groups who are not targeted by current public awareness campaigns.

摘要

背景

公众宣传活动可以针对黑色素瘤的风险因素,以强化防晒信息。本研究的目的是对与恶性黑色素瘤(MM)相关的风险因素进行优先级排序,以提高公众意识。

设计

一项横断面研究,对2004年至2010年的回顾性数据分析。

地点

西澳大利亚黑色素瘤咨询服务中心(WAMAS),一个提供MM管理建议的三级转诊多学科组织。对WAMAS数据文件进行分析,纳入经组织学确诊的皮肤MM患者。47例患者有两个或更多黑色素瘤,但患者档案仅计一次。排除6份信息缺失或不完整的MM数据文件。

主要观察指标

收集的主要变量为痣的数量、患MM的血亲以及既往晒伤情况。

结果

结果显示,70.9%(268/378)有既往晒伤史;40.2%(152/378)有多个痣;22.5%(85/378)有阳性家族史。在110份与晒伤无关的MM数据文件中,多个痣和阳性家族史分别占34.5%(38/110)和20.0%(22/110)。

结论

结果证实了先前研究的发现,即多个痣和阳性家族史是与MM相关的重要风险因素。我们建议,通过关注这些目前公众宣传活动未针对的高危人群,可以更早地发现MM并降低其死亡率。

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