• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

他汀类药物对成年雄性啮齿动物创伤性脑损伤后认知缺陷的影响：一项系统综述

Impact of statins on cognitive deficits in adult male rodents after traumatic brain injury: a systematic review.

作者信息

Peng Weijun, Yang Jingjing, Yang Bo, Wang Lexing, Xiong Xin-gui, Liang Qinghua

机构信息

Institute of Integrated Medicine, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, Hunan 410008, China ; Key Laboratory of Chinese Gan of State Administration of Traditional Chinese Medicine, Changsha 410008, China.

Institute of Integrated Medicine, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, Hunan 410008, China.

出版信息

Biomed Res Int. 2014;2014:261409. doi: 10.1155/2014/261409. Epub 2014 Jul 23.

DOI:10.1155/2014/261409
PMID:25157352
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4135130/
Abstract

The efficacy of statin treatment on cognitive decline is controversial, and the effect of statins on cognitive deficits in individuals with traumatic brain injury (TBI) has yet to be investigated. Therefore, we systematically reviewed the effect of statins on cognitive deficits in adult male rodents after TBI. After identifying eligible studies by searching four electronic databases on February 28, 2014, we assessed study quality, evaluated the efficacy of statin treatment, and performed stratified metaregression and metaregression to assess the influence of study design on statin efficacy. Eleven studies fulfilled our inclusion criteria from a total of 183 publications. The overall methodological quality of these studies was poor. Meta-analysis showed that statins exert statistically significant positive effects on cognitive performance after TBI. Stratified analysis showed that atorvastatin has the greatest effect on acquisition memory, simvastatin has the greatest effect on retention memory, and statin effects on acquisition memory are higher in closed head injury models. Metaregression analysis further showed that that animal species, study quality, and anesthetic agent impact statin effects on retention memory. We conclude that statins might reduce cognitive deficits after TBI. However, additional well-designed and well-reported animal studies are needed to inform further clinical study.

摘要

他汀类药物治疗对认知功能衰退的疗效存在争议，且他汀类药物对创伤性脑损伤（TBI）个体认知缺陷的影响尚未得到研究。因此，我们系统回顾了他汀类药物对成年雄性啮齿动物TBI后认知缺陷的影响。在通过检索四个电子数据库确定符合条件的研究后，我们评估了研究质量，评估了他汀类药物治疗的疗效，并进行了分层Meta回归和Meta回归以评估研究设计对他汀类药物疗效的影响。从总共183篇出版物中筛选出11项符合我们纳入标准的研究。这些研究的整体方法学质量较差。Meta分析表明，他汀类药物对TBI后的认知表现具有统计学显著的积极影响。分层分析表明，阿托伐他汀对获取记忆的影响最大，辛伐他汀对保留记忆的影响最大，且在闭合性颅脑损伤模型中他汀类药物对获取记忆的影响更高。Meta回归分析进一步表明，动物物种、研究质量和麻醉剂会影响他汀类药物对保留记忆的作用。我们得出结论，他汀类药物可能会减少TBI后的认知缺陷。然而，需要更多设计良好且报告充分的动物研究为进一步的临床研究提供信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/465c/4135130/9f6e1f17f0df/BMRI2014-261409.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/465c/4135130/649b54e50089/BMRI2014-261409.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/465c/4135130/cd9ceb49fa95/BMRI2014-261409.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/465c/4135130/e9e707530000/BMRI2014-261409.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/465c/4135130/afe844c4868e/BMRI2014-261409.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/465c/4135130/0579764a2bc9/BMRI2014-261409.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/465c/4135130/2a76a04e3e5b/BMRI2014-261409.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/465c/4135130/9f6e1f17f0df/BMRI2014-261409.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/465c/4135130/649b54e50089/BMRI2014-261409.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/465c/4135130/cd9ceb49fa95/BMRI2014-261409.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/465c/4135130/e9e707530000/BMRI2014-261409.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/465c/4135130/afe844c4868e/BMRI2014-261409.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/465c/4135130/0579764a2bc9/BMRI2014-261409.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/465c/4135130/2a76a04e3e5b/BMRI2014-261409.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/465c/4135130/9f6e1f17f0df/BMRI2014-261409.007.jpg

相似文献

1
Impact of statins on cognitive deficits in adult male rodents after traumatic brain injury: a systematic review.他汀类药物对成年雄性啮齿动物创伤性脑损伤后认知缺陷的影响：一项系统综述
Biomed Res Int. 2014;2014:261409. doi: 10.1155/2014/261409. Epub 2014 Jul 23.
2
Pharmacotherapy for chronic cognitive impairment in traumatic brain injury.创伤性脑损伤慢性认知障碍的药物治疗
Cochrane Database Syst Rev. 2015 Dec 1;2015(12):CD009221. doi: 10.1002/14651858.CD009221.pub2.
3
The impact of ginsenosides on cognitive deficits in experimental animal studies of Alzheimer's disease: a systematic review.人参皂苷对阿尔茨海默病实验动物研究中认知缺陷的影响：一项系统综述。
BMC Complement Altern Med. 2015 Oct 24;15:386. doi: 10.1186/s12906-015-0894-y.
4
Technological aids for the rehabilitation of memory and executive functioning in children and adolescents with acquired brain injury.脑损伤儿童和青少年记忆与执行功能康复的技术辅助手段。
Cochrane Database Syst Rev. 2016 Jul 1;7(7):CD011020. doi: 10.1002/14651858.CD011020.pub2.
5
Statins for Smith-Lemli-Opitz syndrome.他汀类药物治疗 Smith-Lemli-Opitz 综合征。
Cochrane Database Syst Rev. 2022 Nov 14;11(11):CD013521. doi: 10.1002/14651858.CD013521.pub2.
6
A systematic review and economic evaluation of statins for the prevention of coronary events.他汀类药物预防冠状动脉事件的系统评价与经济学评估
Health Technol Assess. 2007 Apr;11(14):1-160, iii-iv. doi: 10.3310/hta11140.
7
Progesterone for acute traumatic brain injury.孕酮用于急性创伤性脑损伤。
Cochrane Database Syst Rev. 2016 Dec 22;12(12):CD008409. doi: 10.1002/14651858.CD008409.pub4.
8
Perioperative statin therapy for improving outcomes during and after noncardiac vascular surgery.围手术期他汀类药物治疗以改善非心脏血管手术期间及术后的结局。
Cochrane Database Syst Rev. 2013 Jul 3;2013(7):CD009971. doi: 10.1002/14651858.CD009971.pub2.
9
Statin treatment in multiple sclerosis: a systematic review and meta-analysis.他汀类药物治疗多发性硬化症：一项系统评价与荟萃分析。
CNS Drugs. 2015 Apr;29(4):277-91. doi: 10.1007/s40263-015-0239-x.
10
Statins for non-alcoholic fatty liver disease and non-alcoholic steatohepatitis.用于非酒精性脂肪性肝病和非酒精性脂肪性肝炎的他汀类药物。
Cochrane Database Syst Rev. 2013 Dec 27;2013(12):CD008623. doi: 10.1002/14651858.CD008623.pub2.

引用本文的文献

1
Whole body vibration ameliorates anxiety-like behavior and memory functions in 30 months old senescent male rats.全身振动改善30月龄雄性衰老大鼠的焦虑样行为和记忆功能。
Heliyon. 2024 Feb 16;10(4):e26608. doi: 10.1016/j.heliyon.2024.e26608. eCollection 2024 Feb 29.
2
Therapeutic potential of curcumin on the cognitive decline in animal models of Alzheimer's disease: a systematic review and meta-analysis.姜黄素对阿尔茨海默病动物模型认知功能衰退的治疗潜力：一项系统综述与荟萃分析
Naunyn Schmiedebergs Arch Pharmacol. 2024 Jul;397(7):4499-4509. doi: 10.1007/s00210-024-02946-7. Epub 2024 Jan 24.
3
The neuroprotective effect of statin in traumatic brain injury: A systematic review.

本文引用的文献

1
Systematic review and meta-analysis of randomized controlled trials of xingnaojing treatment for stroke.醒脑静治疗脑卒中的随机对照试验的系统评价和荟萃分析。
Evid Based Complement Alternat Med. 2014;2014:210851. doi: 10.1155/2014/210851. Epub 2014 Feb 24.
2
Cognitive sequelae of traumatic brain injury.创伤性脑损伤的认知后遗症。
Psychiatr Clin North Am. 2014 Mar;37(1):1-11. doi: 10.1016/j.psc.2013.11.004. Epub 2014 Jan 14.
3
Statins and cognitive function: a systematic review.他汀类药物与认知功能：系统评价。
他汀类药物在创伤性脑损伤中的神经保护作用：一项系统综述。
World Neurosurg X. 2023 May 13;19:100211. doi: 10.1016/j.wnsx.2023.100211. eCollection 2023 Jul.
4
The Effect of Oral Simvastatin on the Clinical Outcome of Patients with Severe Traumatic Brain Injury: A Randomized Clinical Trial.口服辛伐他汀对严重创伤性脑损伤患者临床结局的影响：一项随机临床试验。
Ethiop J Health Sci. 2021 Jul;31(4):807-816. doi: 10.4314/ejhs.v31i4.15.
5
Chronic Traumatic Encephalopathy: Update on Current Clinical Diagnosis and Management.慢性创伤性脑病：当前临床诊断与管理的最新进展
Biomedicines. 2021 Apr 12;9(4):415. doi: 10.3390/biomedicines9040415.
6
Inflammation in Traumatic Brain Injury.颅脑创伤中的炎症反应。
J Alzheimers Dis. 2020;74(1):1-28. doi: 10.3233/JAD-191150.
7
Novel therapies for combating chronic neuropathological sequelae of TBI.治疗创伤性脑损伤慢性神经病理后遗症的新疗法。
Neuropharmacology. 2019 Feb;145(Pt B):160-176. doi: 10.1016/j.neuropharm.2018.06.021. Epub 2018 Jun 20.
8
Potential immunotherapies for traumatic brain and spinal cord injury.创伤性脑损伤和脊髓损伤的潜在免疫疗法。
Chin J Traumatol. 2018 Jun;21(3):125-136. doi: 10.1016/j.cjtee.2018.02.002. Epub 2018 Apr 18.
9
Early to Long-Term Alterations of CNS Barriers After Traumatic Brain Injury: Considerations for Drug Development.颅脑创伤后中枢神经系统屏障的早期及长期改变：药物研发的相关考虑。
AAPS J. 2017 Nov;19(6):1615-1625. doi: 10.1208/s12248-017-0123-3. Epub 2017 Sep 13.
10
Impact of 2, 3, 5, 4'-tetrahydroxystilbene-2-O-β-D-glucoside on cognitive deficits in animal models of Alzheimer's disease: a systematic review.2,3,5,4'-四羟基二苯乙烯-2-O-β-D-葡萄糖苷对阿尔茨海默病动物模型认知缺陷的影响：一项系统综述
BMC Complement Altern Med. 2016 Aug 26;16(1):320. doi: 10.1186/s12906-016-1313-8.
Ann Intern Med. 2013 Nov 19;159(10):688-97. doi: 10.7326/0003-4819-159-10-201311190-00007.
4
Meta-analysis of data from animal studies: a practical guide.动物研究数据的荟萃分析：实用指南。
J Neurosci Methods. 2014 Jan 15;221:92-102. doi: 10.1016/j.jneumeth.2013.09.010. Epub 2013 Oct 4.
5
Molecular mechanisms of cognitive dysfunction following traumatic brain injury.颅脑损伤后认知功能障碍的分子机制。
Front Aging Neurosci. 2013 Jul 9;5:29. doi: 10.3389/fnagi.2013.00029. eCollection 2013.
6
Histone deacetylase inhibitors are neuroprotective and preserve NGF-mediated cell survival following traumatic brain injury.组蛋白去乙酰化酶抑制剂具有神经保护作用，并能维持创伤性脑损伤后神经营养因子介导的细胞存活。
Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10747-52. doi: 10.1073/pnas.1308950110. Epub 2013 Jun 10.
7
Systematic review and stratified meta-analysis of the efficacy of RhoA and Rho kinase inhibitors in animal models of ischaemic stroke.系统评价和分层荟萃分析 RhoA 和 Rho 激酶抑制剂在缺血性中风动物模型中的疗效。
Syst Rev. 2013 May 20;2:33. doi: 10.1186/2046-4053-2-33.
8
Animal models of traumatic brain injury.创伤性脑损伤的动物模型。
Nat Rev Neurosci. 2013 Feb;14(2):128-42. doi: 10.1038/nrn3407.
9
Incidence of traumatic brain injury in New Zealand: a population-based study.新西兰创伤性脑损伤的发生率：一项基于人群的研究。
Lancet Neurol. 2013 Jan;12(1):53-64. doi: 10.1016/S1474-4422(12)70262-4. Epub 2012 Nov 22.
10
Effects of atorvastatin in the regulation of circulating EPCs and angiogenesis in traumatic brain injury in rats.阿托伐他汀对大鼠创伤性脑损伤中循环内皮祖细胞及血管生成的调节作用。
J Neurol Sci. 2012 Aug 15;319(1-2):117-23. doi: 10.1016/j.jns.2012.04.015. Epub 2012 Jun 2.