2,3,5,4'-四羟基二苯乙烯-2-O-β-D-葡萄糖苷对阿尔茨海默病动物模型认知缺陷的影响：一项系统综述

Impact of 2, 3, 5, 4'-tetrahydroxystilbene-2-O-β-D-glucoside on cognitive deficits in animal models of Alzheimer's disease: a systematic review.

作者信息

Sheng Chenxia, Peng Weijun, Chen Zeqi, Cao Yucheng, Gong Wei, Xia Zi-An, Wang Yang, Su Nanxiang, Wang Zhe

机构信息

Department of Integrated Traditional Chinese & Western Medicine, The Second Xiangya Hospital, Central South University, No.139 Middle Renmin Road, Changsha, Hunan, 410011, People's Republic of China.

Department of Integrated Traditional Chinese & Western Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China.

出版信息

BMC Complement Altern Med. 2016 Aug 26;16(1):320. doi: 10.1186/s12906-016-1313-8.

DOI:10.1186/s12906-016-1313-8

PMID:27565551

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5002158/

Abstract

BACKGROUND

The efficacy of 2, 3, 5, 4'-tetrahydroxystilbene-2-O-β-D-glucoside (TSG) treatment on cognitive decline in individuals with Alzheimer's disease (AD) has not been investigated. Therefore, we systematically reviewed the effect of TSG on cognitive deficits in a rodent model of AD.

METHODS

We identified eligible studies published from January 1980 to April 2015 by searching seven electronic databases. We assessed the study quality, evaluated the efficacy of TSG treatment, and performed a stratified meta-analysis and meta-regression analysis to assess the influence of study design on TSG efficacy.

RESULTS

Among a total of 381 publications, 18 fulfilled our inclusion criteria. The overall methodological quality of these studies was poor. The meta-analysis revealed a statistically significant benefit of TSG on acquisition memory (standardized mean difference [SMD] = -1.46 (95 % CI: -1.81 to -1.10, P < 0.0001) and retention memory (SMD =1.93 (95 % CI: 1.40 to 2.46, P < 0.0001) in experimental models of AD. The stratified analysis revealed a significantly higher effect size for both acquisition and retention memory in studies that used mixed sex models and a significantly higher effect size for acquisition memory in studies that used transgenic models.

CONCLUSIONS

Our meta-analysis highlights a significantly better treatment effect in rodent AD models that received TSG that in those that did not. These findings indicate a potential therapeutic role of TSG in AD therapy. However, additional well-designed and detailed experimental studies are needed to evaluate the safety of TSG.

摘要

背景

2,3,5,4'-四羟基二苯乙烯-2-O-β-D-葡萄糖苷（TSG）治疗阿尔茨海默病（AD）患者认知功能衰退的疗效尚未得到研究。因此，我们系统评价了TSG对AD啮齿动物模型认知缺陷的影响。

方法

通过检索7个电子数据库，我们确定了1980年1月至2015年4月发表的符合条件的研究。我们评估了研究质量，评价了TSG治疗的疗效，并进行了分层荟萃分析和荟萃回归分析，以评估研究设计对TSG疗效的影响。

结果

在总共381篇出版物中，18篇符合我们的纳入标准。这些研究的总体方法学质量较差。荟萃分析显示，在AD实验模型中，TSG对获得性记忆（标准化均数差[SMD]=-1.46（95%CI：-1.81至-1.10，P<0.0001）和保留性记忆（SMD=1.93（95%CI：1.40至2.46，P<0.0001）有统计学显著益处。分层分析显示，在使用混合性别模型的研究中，获得性记忆和保留性记忆的效应量均显著更高；在使用转基因模型的研究中，获得性记忆的效应量显著更高。