Sönnerborg A B, von Sydow M A, Forsgren M, Strannegård O O
Department of Virology, Stockholm County Council, Sweden.
AIDS. 1989 Nov;3(11):701-5. doi: 10.1097/00002030-198911000-00003.
The levels of antibodies to HIV-1 and the occurrence of HIV-1 were determined in the cerebrospinal fluid (CSF) and the blood of 60 people in various stages of HIV-1 infection. Intrathecal synthesis of anti-HIV-1 immunoglobulin (Ig) G was detectable at a low frequency in individuals with normal immunological parameters, and in the majority of patients with various degrees of immunodeficiency. The intrathecal production of antibodies to HIV-1 was strongly associated with the recovery of the virus from CSF. A relationship between high anti-HIV-1 IgG levels and occurrence of HIV-1 was also found in blood. Patients without overt neurological symptoms exhibited intrathecal synthesis of anti-HIV-1 IgG as often as those with such symptoms. These findings suggest that intrathecal synthesis of antibodies to HIV-1 is related to a persistent HIV-1 antigenic stimulation in the central nervous system (CNS). HIV-1 often seems to elicit a humoral immune response in the CNS, without concomitant overt neurological symptoms.
在60名处于不同HIV-1感染阶段的人群的脑脊液（CSF）和血液中，测定了HIV-1抗体水平及HIV-1的出现情况。在免疫参数正常的个体以及大多数有不同程度免疫缺陷的患者中，均可低频率检测到抗HIV-1免疫球蛋白（Ig）G的鞘内合成。HIV-1抗体的鞘内产生与从脑脊液中分离出病毒密切相关。在血液中也发现高抗HIV-1 IgG水平与HIV-1的出现之间存在关联。没有明显神经症状的患者与有此类症状的患者一样，常出现抗HIV-1 IgG的鞘内合成。这些发现表明，抗HIV-1抗体的鞘内合成与中枢神经系统（CNS）中持续的HIV-1抗原刺激有关。HIV-1似乎常常在中枢神经系统引发体液免疫反应，而不伴有明显的神经症状。
