Adeoye Opeolu, Albright Karen C, Carr Brendan G, Wolff Catherine, Mullen Micheal T, Abruzzo Todd, Ringer Andrew, Khatri Pooja, Branas Charles, Kleindorfer Dawn
From the University of Cincinnati Neuroscience Institute, OH (O.A., T.A., A.R., P.K., D.K.); Department of Emergency Medicine (O.A.), Department of Neurosurgery (O.A., T.A., A.R.), and Department of Neurology (P.K., D.K.), University of Cincinnati, OH; Department of Neurology, University of Alabama at Birmingham (K.C.A.); and Department of Biostatistics and Epidemiology (B.G.C., C.W., C.B.), Department of Emergency Medicine (B.G.C.), and Department of Neurology (M.T.M.), University of Pennsylvania, Philadelphia.
Stroke. 2014 Oct;45(10):3019-24. doi: 10.1161/STROKEAHA.114.006293. Epub 2014 Aug 26.
Only 3% to 5% of patients with acute ischemic stroke receive intravenous recombinant tissue-type plasminogen activator (r-tPA) and <1% receive endovascular therapy. We describe access of the US population to all facilities that actually provide intravenous r-tPA or endovascular therapy for acute ischemic stroke.
We used US demographic data and intravenous r-tPA and endovascular therapy rates in the 2011 US Medicare Provider and Analysis Review data set. International Classification of Diseases-Ninth Revision codes 433.xx, 434.xx and 436 identified acute ischemic stroke cases. International Classification of Diseases-Ninth Revision code 99.10 defined intravenous r-tPA treatment and International Classification of Diseases-Ninth Revision code 39.74 defined endovascular therapy. We estimated ambulance response times using arc-Geographic Information System's network analyst and helicopter transport times using validated models. Population access to care was determined by summing the population contained within travel sheds that could reach capable hospitals within 60 and 120 minutes.
Of 370,351 acute ischemic stroke primary diagnosis discharges, 14,926 (4%) received intravenous r-tPA and 1889 (0.5%) had endovascular therapy. By ground, 81% of the US population had access to intravenous-capable hospitals within 60 minutes and 56% had access to endovascular-capable hospitals. By air, 97% had access to intravenous-capable hospitals within 60 minutes and 85% had access to endovascular hospitals. Within 120 minutes, 99% of the population had access to both intravenous and endovascular hospitals.
More than half of the US population has geographic access to hospitals that actually deliver acute stroke care but treatment rates remain low. These data provide a national perspective on acute stroke care and should inform the planning and optimization of stroke systems in the United States.
仅有3%至5%的急性缺血性卒中患者接受静脉注射重组组织型纤溶酶原激活剂(r - tPA)治疗,接受血管内治疗的患者比例不到1%。我们描述了美国人群获得实际提供急性缺血性卒中静脉r - tPA或血管内治疗的所有机构的情况。
我们使用了美国人口统计数据以及2011年美国医疗保险提供者与分析审查数据集中的静脉r - tPA和血管内治疗率。国际疾病分类第九版(ICD - 9)编码433.xx、434.xx和436识别急性缺血性卒中病例。ICD - 9编码99.10定义静脉r - tPA治疗,ICD - 9编码39.74定义血管内治疗。我们使用弧形地理信息系统的网络分析器估计救护车响应时间,并使用经过验证的模型估计直升机运输时间。通过汇总在60分钟和120分钟内能够到达有能力的医院的行程范围内的人口数量,来确定人群获得医疗服务的情况。
在370351例急性缺血性卒中主要诊断出院病例中,14926例(4%)接受了静脉r - tPA治疗,1889例(0.5%)接受了血管内治疗。通过地面交通,81%的美国人口在60分钟内可到达有能力进行静脉治疗的医院,56%的人口可到达有能力进行血管内治疗的医院。通过空中交通,97%的人口在60分钟内可到达有能力进行静脉治疗的医院,85%的人口可到达有血管内治疗能力的医院。在120分钟内,99%的人口可到达有静脉和血管内治疗能力的医院。
超过一半的美国人口在地理上可获得实际提供急性卒中治疗的医院,但治疗率仍然较低。这些数据提供了关于急性卒中治疗的全国视角,应为美国卒中系统的规划和优化提供参考。