Department of Chemistry, Girls Campus, King Abdulaziz University, P.O. Box 6171, Jeddah 21442, Saudi Arabia.
Department of Chemistry, Faculty of Science, Assiut University, Assiut 71516, Egypt.
Bioorg Chem. 2014 Dec;57:5-12. doi: 10.1016/j.bioorg.2014.07.004. Epub 2014 Jul 30.
Transition metal complexes compounds with Schiff bases ligand representing an important class of compounds that could be used to develop new metal-based anticancer agents and as precursors of metal NPs. Herein, 2,3-bis-[(3-ethoxy-2-hydroxybenzylidene)amino]but-2-enedinitrile Schiff base ligand and its corresponding copper/nickel complexes were synthesized. Also, we reported a facile and rapid method for synthesis nickel/copper nanoparticles based on thermal reduction of their complexes. Free ligand, its metal complexes and metals nanoparticles have been characterized based on elemental analysis, transmission electron microscopy, powder X-ray diffraction, magnetic measurements and by various spectroscopic (UV-vis, FT-IR, (1)H NMR, GC-MS) techniques. Additionally, the in vitro cytotoxic activity of free ligand and its complexes compounds were assessed against two cancer cell lines (HeLa and MCF-7 cells)and one healthy cell line (HEK293 cell). The copper complex was found to be active against these cancer cell lines at very low LD50 than the free ligand, while nickel complex did not show any anticancer activity against these cell lines. Also, the antibacterial activity of as-prepared copper nanoparticles were screened against Escherichia coli, which demonstrated minimum inhibitory concentration and minimum bactericidal concentration values lower than those values of the commercial Cu NPs as well as the previous reported values. Moreover, the synthesized nickel nanoparticles demonstrated remarkable catalytic performance toward hydrogenation of nitrobenzene that producing clean aniline with high selectivity (98%). This reactivity could be attributed to the high degree of dispersion of Ni nanoparticles.
过渡金属配合物与席夫碱配体代表了一类重要的化合物，可用于开发新型基于金属的抗癌药物和作为金属 NPs 的前体。在此，合成了 2,3-双-[(3-乙氧基-2-羟基亚苄基)氨基]丁-2-烯二腈席夫碱配体及其相应的铜/镍配合物。此外，我们还报道了一种基于其配合物热还原的简便、快速合成镍/铜纳米粒子的方法。游离配体、其金属配合物和金属纳米粒子已通过元素分析、透射电子显微镜、粉末 X 射线衍射、磁性测量和各种光谱（UV-vis、FT-IR、(1)H NMR、GC-MS）技术进行了表征。此外，还评估了游离配体及其配合物化合物对两种癌细胞系（HeLa 和 MCF-7 细胞）和一种健康细胞系（HEK293 细胞）的体外细胞毒性活性。铜配合物对这些癌细胞系的活性在非常低的 LD50 下比游离配体高，而镍配合物对这些细胞系没有显示出任何抗癌活性。此外，所制备的铜纳米粒子的抗菌活性也针对大肠杆菌进行了筛选，其最低抑菌浓度和最低杀菌浓度值均低于商业 Cu NPs 以及之前报道的值。此外，合成的镍纳米粒子在硝基苯的加氢反应中表现出优异的催化性能，生成高选择性（98%）的清洁苯胺。这种反应性可以归因于 Ni 纳米粒子的高分散度。
