Mousa Emad, Tammam Ahmed K, Refaat Ahmed M, Mohamed Gehad G
Physics Department, Faculty of Science, Cairo University, Giza, Egypt.
Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt.
Sci Rep. 2025 Aug 25;15(1):31202. doi: 10.1038/s41598-025-16628-8.
Schiff base complexes possess biological activity and electronic features, making them suitable for integration into both core and auxiliary components of bioelectronic technologies. However, integrated studies addressing their electrical, biological, and mechanical properties remain limited. This work investigates a Cu(II) complex based on a Schiff base ligand derived from 2-hydroxy-1-naphthaldehyde and 1,8-diaminonaphthalene. Comprehensive textural analyses using XRD, HRTEM, FESEM, AFM, and N₂ adsorption revealed high surface area, nanoscale morphology, and porosity, which are advantageous for antimicrobial and therapeutic bioelectronic platforms. Mechanical characterization via ultrasonic pulse-echo indicated auxetic behavior, a rare and valuable trait for flexible substrates. The complex also exhibited high ionic conductivity, facilitating charge transport in aqueous environments and contributing to antimicrobial efficacy through ionic disruption of microbial membranes. Thermal analyses showed a phase transition at 44 °C and decomposition onset at 70 °C. A temperature-induced insulator-to-metal transition was observed, suggesting potential for thermally activated sensing, temperature-triggered drug release, and adaptive signal modulation. Biological assays confirmed strong antimicrobial activity, with a 30 mm inhibition zone against Bacillus subtilis (agar well diffusion), and potent cytotoxicity against MCF-7 breast cancer cells, with an IC₅₀ of 18.4 μg/mL (MTT assay). These biological properties enhance the complex's biocompatibility and support its role in long-term bioelectronic device stability, particularly in applications where infection control is essential.
席夫碱配合物具有生物活性和电子特性，使其适合集成到生物电子技术的核心和辅助组件中。然而，针对其电学、生物学和机械性能的综合研究仍然有限。这项工作研究了一种基于由2-羟基-1-萘甲醛和1,8-二氨基萘衍生的席夫碱配体的铜（II）配合物。使用XRD、HRTEM、FESEM、AFM和N₂吸附进行的综合结构分析表明，该配合物具有高表面积、纳米级形态和孔隙率，这对于抗菌和治疗性生物电子平台是有利的。通过超声脉冲回波进行的机械表征表明其具有负泊松比行为，这对于柔性基板来说是一种罕见且有价值的特性。该配合物还表现出高离子电导率，有利于在水性环境中进行电荷传输，并通过对微生物膜的离子破坏促进抗菌效果。热分析表明在44°C发生相变，在70°C开始分解。观察到温度诱导的绝缘体-金属转变，表明其在热激活传感、温度触发药物释放和自适应信号调制方面具有潜力。生物学试验证实了其强大的抗菌活性，对枯草芽孢杆菌的抑菌圈为30mm（琼脂孔扩散法），对MCF-7乳腺癌细胞具有强大的细胞毒性，IC₅₀为18.4μg/mL（MTT法）。这些生物学特性增强了该配合物的生物相容性，并支持其在长期生物电子器件稳定性中的作用，特别是在感染控制至关重要的应用中。
