图雷特综合征与破坏性行为障碍：患病率、关联及相关关系的解释。
Gilles de la Tourette syndrome and disruptive behavior disorders: prevalence, associations, and explanation of the relationships.
机构信息
From the University College London; the Dept. of Neurology, Atkinson Morley Wing, St. Georges Hospital and Medical School, London; the Dept. of Neuropsychiatry, BSMHFT and University of Birmingham, United Kingdom; the School of Life and Health Sciences, Aston University, Birmingham, United Kingdom; the Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London; the School of Psychiatry and Ingham Institute, University of New South Wales, Sydney, Australia; and the Academic Unit of Child Psychiatry, South Western Sydney Local Health District, Sydney, Australia.
出版信息
J Neuropsychiatry Clin Neurosci. 2015 Winter;27(1):33-41. doi: 10.1176/appi.neuropsych.13050112. Epub 2014 Oct 31.
Gilles de la Tourette syndrome and conduct disorder (CD) are both heterogeneous childhood onset conditions, and although patients with CD have been described in Gilles de la Tourette syndrome cohorts, little is known about the etiology of CD in Gilles de la Tourette syndrome or of the interrelationships. A cohort of 578 consecutive patients with Gilles de la Tourette syndrome was assessed using standard assessment protocols. A total of 13.5% of participants had only Gilles de la Tourette syndrome, whereas the rest had associated comorbidities and psychopathology. CD occurred in 14.5% of Gilles de la Tourette syndrome probands. These findings suggest that CD is not an integral part of Gilles de la Tourette syndrome but rather that CD in the context of Gilles de la Tourette syndrome is related to the presence of attention deficit hyperactivity disorder, as well as, and importantly, a family history of aggressive and violent behavior and forensic encounters.
妥瑞氏症候群与品行障碍（CD）均为异质性的儿童期发病疾病，虽然在妥瑞氏症候群患者群体中已有品行障碍患者的描述，但关于妥瑞氏症候群中的品行障碍的病因或相互关系知之甚少。使用标准评估方案评估了 578 例连续的妥瑞氏症候群患者。参与者中有 13.5%仅有妥瑞氏症候群，而其余患者则存在相关共病和精神病理学。14.5%的妥瑞氏症候群先证者患有 CD。这些发现表明 CD 不是妥瑞氏症候群的固有组成部分，而是妥瑞氏症候群中的 CD 与注意缺陷多动障碍的存在有关，以及重要的是，具有攻击性和暴力行为以及法医接触的家族史有关。
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