硫必利和托吡酯对抽动秽语综合征患儿抽动严重程度及行为/情绪问题的影响：一项回顾性研究
Influence of Tiapride and Topiramate on Tic Severity and Behavioral/Emotional Problems in Children with Tourette Syndrome: A Retrospective Study.
作者信息
Zhou Xuanzi, Liao Zhaoying, Li Yi, Wang Nanqing, Xiao Nong
机构信息
Department of Rehabilitation, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400010, China.
China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing 400010, China.
出版信息
Brain Sci. 2023 Feb 22;13(3):383. doi: 10.3390/brainsci13030383.
OBJECTIVES
To investigate the effect of tiapride and topiramate on patients with Tourette syndrome (TS).
METHODS
This retrospective analysis included 126 children diagnosed with TS at Children's Hospital of Chongqing Medical University from 2019 to 2021, with treatment including tiapride (n = 60) and topiramate (n = 66). Their tic severity values were assessed with the Yale Global Tic Severity Scale (YGTSS). Furthermore, behavioral and emotional problems were assessed with the Conner's Parent Rating Scale (CPRS) and the Children Behavior Checklist (CBCL).
RESULTS
Compared with premedication, the scores of tic severity were significantly decreased in both tiapride and topiramate groups after treatment, especially topiramate. Moreover, it was noted that five subscores of CPRS were significantly reduced in TS patients thanks to medication. However, there was no significant difference in CBCL after treatment, in both tiapride and topiramate groups.
CONCLUSIONS
Tiapride and topiramate were proven to be effective on tics and some behavioral/emotional problems in TS patients, and topiramate may provide better treatment.
目的
探讨硫必利和托吡酯对抽动秽语综合征（TS）患者的疗效。
方法
本回顾性分析纳入了2019年至2021年在重庆医科大学附属儿童医院诊断为TS的126例儿童，治疗方法包括硫必利（n = 60）和托吡酯（n = 66）。采用耶鲁全球抽动严重程度量表（YGTSS）评估他们的抽动严重程度值。此外，采用康纳斯父母评定量表（CPRS）和儿童行为量表（CBCL）评估行为和情绪问题。
结果
与用药前相比，硫必利组和托吡酯组治疗后抽动严重程度评分均显著降低，尤其是托吡酯组。此外，值得注意的是，药物治疗使TS患者的CPRS五个子评分显著降低。然而，硫必利组和托吡酯组治疗后CBCL评分均无显著差异。
结论
硫必利和托吡酯被证明对TS患者的抽动及一些行为/情绪问题有效，且托吡酯可能提供更好的治疗效果。
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