Thomsen J S, Jensen M V, Niklassen A S, Ebbesen E N, Brüel A
Department of Biomedicine-Anatomy, Aarhus University, Wilhelm Meyers Allé 3, 8000, Aarhus C, Denmark,
Osteoporos Int. 2015 Jan;26(1):219-28. doi: 10.1007/s00198-014-2851-x. Epub 2014 Aug 28.
Age-related changes of vertebra and iliac crest 3D microstructure were investigated, and we showed that they were in general similar. The 95th percentile of vertebral trabecular thickness distribution increased with age for women. Surprisingly, vertebral and iliac crest bone microstructure was only weakly correlated (r = 0.38 to 0.75), despite the overall similar age-related changes.
The purposes of the study were to determine the age-related changes in iliac and vertebral bone microstructure for women and men over a large age range and to investigate the relationship between the bone microstructure at these skeletal sites.
Matched sets of transiliac crest bone biopsies and lumbar vertebral body (L2) specimens from 41 women (19-96 years) and 39 men (23-95 years) were micro-computed tomography (μCT) scanned, and the 3D microstructure was quantified.
For both women and men, bone volume per total volume (BV/TV), connectivity density (CD), and trabecular number (Tb.N) decreased significantly, while structure model index (SMI) and trabecular separation (Tb.Sp) increased significantly with age at either skeletal site. Vertebral trabecular thickness (Tb.Th) was independent of age for both women and men, while iliac Tb.Th decreased significantly with age for men, but not for women. In general, the vertebral and iliac age-related changes were similar. The 95th percentile of the Tb.Th distribution increased significantly with age for women but was independent of age for men at the vertebral body, while it was independent of age for either sex at the iliac crest. The Tb.Th probability density functions at the two skeletal sites became significantly more similar with age for women, but not for men. The microstructural parameters at the iliac crest and the vertebral bodies were only moderately correlated from r = 0.38 for SMI in women to r = 0.75 for Tb.Sp in men.
Age-related changes in vertebral and iliac bone microstructure were in general similar. The iliac and vertebral Tb.Th distributions became more similar with age for women. Despite the overall similar age-related changes in trabecular bone microstructure, the vertebral and iliac bone microstructural measures were only weakly correlated (r = 0.38 to 0.75).
研究了椎骨和髂嵴的三维微观结构随年龄的变化，结果表明它们总体上相似。女性椎骨小梁厚度分布的第95百分位数随年龄增加。令人惊讶的是，尽管总体上年龄相关变化相似，但椎骨和髂嵴的骨微观结构仅呈弱相关（r = 0.38至0.75）。
本研究的目的是确定不同年龄段女性和男性髂骨和椎骨骨微观结构的年龄相关变化，并研究这些骨骼部位的骨微观结构之间的关系。
对41名女性（19 - 96岁）和39名男性（23 - 95岁）的配对髂嵴骨活检样本和腰椎椎体（L2）标本进行显微计算机断层扫描（μCT），并对三维微观结构进行量化。
对于女性和男性，两个骨骼部位的骨体积占总体积的比例（BV/TV）、连通性密度（CD）和小梁数量（Tb.N）均显著下降，而结构模型指数（SMI）和小梁间距（Tb.Sp）随年龄显著增加。女性和男性的椎骨小梁厚度（Tb.Th）均与年龄无关，而男性髂骨的Tb.Th随年龄显著下降，女性则不然。总体而言，椎骨和髂嵴的年龄相关变化相似。女性椎骨部位Tb.Th分布的第95百分位数随年龄显著增加，而男性则与年龄无关，在髂嵴部位，无论男女，Tb.Th均与年龄无关。随着年龄增长，女性两个骨骼部位的Tb.Th概率密度函数变得显著更相似，男性则不然。髂嵴和椎体的微观结构参数仅呈中度相关，女性的SMI相关系数为r = 0.38，男性的Tb.Sp相关系数为r = 0.75。
椎骨和髂骨骨微观结构的年龄相关变化总体上相似。女性髂骨和椎骨的Tb.Th分布随年龄变得更相似。尽管小梁骨微观结构的总体年龄相关变化相似，但椎骨和髂骨的骨微观结构测量值仅呈弱相关（r = 0.38至0.75）。
