Department of Microbiology, Amrita Institute of Medical Sciences & Research Centre, Kochi, Kerala, India.
Department of Microbiology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India.
J Clin Microbiol. 2014 Nov;52(11):4094-9. doi: 10.1128/JCM.01977-14. Epub 2014 Aug 27.
Cases of invasive mycosis due to Blastobotrys serpentis and B. proliferans identified by sequencing in a preterm patient and a rhabdomyosarcoma patient, respectively, are reported. Both species revealed elevated fluconazole and echinocandin MICs by the CLSI broth microdilution method. Additionally, B. serpentis exhibited high amphotericin B MICs, thus posing serious therapeutic challenges.
分别报道了一例早产儿和一例横纹肌肉瘤患者因感染蛇形弯孢霉和增生弯孢霉而导致侵袭性真菌感染的病例。这两个种的氟康唑和棘白菌素 MIC 值均通过 CLSI 肉汤微量稀释法检测升高。此外,蛇形弯孢霉还表现出高浓度两性霉素 B MIC 值,因此带来了严重的治疗挑战。