突尼斯人群中KCNJ11基因E23K变异与2型糖尿病关联的证据：基于人群的研究和荟萃分析。
Evidence for association of the E23K variant of KCNJ11 gene with type 2 diabetes in Tunisian population: population-based study and meta-analysis.
作者信息
Lasram Khaled, Ben Halim Nizar, Hsouna Sana, Kefi Rym, Arfa Imen, Ghazouani Welid, Jamoussi Henda, Benrahma Houda, Kharrat Najla, Rebai Ahmed, Ben Ammar Slim, Bahri Sonia, Barakat Abdelhamid, Abid Abdelmajid, Abdelhak Sonia
机构信息
Pasteur Institute of Tunis, Laboratory of Biomedical Genomics and Oncogenetics, LR11IPT05, BP 74, 13 Place Pasteur, Le Belvédère, 1002 Tunis, Tunisia ; Université Tunis El Manar, 1068 Tunis, Tunisia.
Pasteur Institute of Tunis, Laboratory of Biomedical Genomics and Oncogenetics, LR11IPT05, BP 74, 13 Place Pasteur, Le Belvédère, 1002 Tunis, Tunisia ; National Institute of Nutrition and Food Technology, Department of External Consultation, 11 rue Jebel Lakhdar, Bab Saadoun, 1007 Tunis, Tunisia.
出版信息
Biomed Res Int. 2014;2014:265274. doi: 10.1155/2014/265274. Epub 2014 Jul 7.
AIMS
Genetic association studies have reported the E23K variant of KCNJ11 gene to be associated with Type 2 diabetes. In Arab populations, only four studies have investigated the role of this variant. We aimed to replicate and validate the association between the E23K variant and Type 2 diabetes in Tunisian and Arab populations.
METHODS
We have performed a case-control association study including 250 Tunisian patients with Type 2 diabetes and 267 controls. Allelic association has also been evaluated by 2 meta-analyses including all population-based studies among Tunisians and Arabs (2 and 5 populations, resp.).
RESULTS
A significant association between the E23K variant and Type 2 diabetes was found (OR = 1.6, 95% CI = 1.14-2.27, and P = 0.007). Furthermore, our meta-analysis has confirmed the significant role of the E23K variant in susceptibility of Type 2 diabetes in Tunisian and Arab populations (OR = 1.29, 95% CI = 1.15-1.46, and P < 10(-3) and OR = 1.33, 95% CI = 1.13-1.56, and P = 0.001, resp.).
CONCLUSION
Both case-control and meta-analyses results revealed the significant association between the E23K variant of KCNJ11 and Type 2 diabetes among Tunisians and Arabs.
目的
基因关联研究报告称，KCNJ11基因的E23K变体与2型糖尿病有关。在阿拉伯人群中，仅有四项研究调查了该变体的作用。我们旨在在突尼斯人和阿拉伯人群中重复并验证E23K变体与2型糖尿病之间的关联。
方法
我们开展了一项病例对照关联研究，纳入了250名突尼斯2型糖尿病患者和267名对照。还通过两项荟萃分析评估了等位基因关联，这两项荟萃分析分别纳入了突尼斯人和阿拉伯人基于人群的所有研究（分别为2个和5个群体）。
结果
发现E23K变体与2型糖尿病之间存在显著关联（OR = 1.6，95% CI = 1.14 - 2.27，P = 0.007）。此外，我们的荟萃分析证实了E23K变体在突尼斯人和阿拉伯人群2型糖尿病易感性中的显著作用（OR分别为1.29，95% CI = 1.15 - 1.46，P < 10⁻³；以及OR = 1.33，95% CI = 1.13 - 1.56，P = 0.001）。
结论
病例对照研究和荟萃分析结果均显示，突尼斯人和阿拉伯人群中，KCNJ11基因的E23K变体与2型糖尿病之间存在显著关联。
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