Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Mol Biol Rep. 2013 Jan;40(1):141-6. doi: 10.1007/s11033-012-2042-9. Epub 2012 Oct 11.
Potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) E23K gene polymorphism has been indicated as relevant to type 2 diabetes mellitus (T2D) susceptibility, but research results remain debatable.To investigate the relationship between KCNJ11 E23K gene polymorphism and T2D in the Chinese Han population, a meta-analysis involving 3,080 T2D patients and 3,029 controls from five separate studies was conducted. The pooled odds ratio (ORs) for the association between KCNJ11 E23K gene polymorphism and T2D and its corresponding 95 % confidence interval (95 % CI) were estimated using a random effects model.A significant association was observed between the KCNJ11 E23K gene polymorphism and T2D in the pooled Chinese Han population through an allelic genetic model (OR: 1.21, 95 % CI: 1.04-1.40, P = 0.01) and a recessive genetic model (OR: 1.44, 95 % CI: 1.25-1.65, P < 0.00001). In contrast, no significant association was observed between the KCNJ11 E23K gene polymorphism and T2D in the dominant genetic model (OR: 0.66, 95 % CI: 0.41-1.07, P = 0.09).The KCNJ11 E23K gene polymorphism is associated with T2D risk in the Chinese Han population.
钾离子内向整流通道亚家族 J 成员 11（KCNJ11）E23K 基因多态性与 2 型糖尿病（T2D）易感性相关，但研究结果仍存在争议。为了探讨 KCNJ11 E23K 基因多态性与中国汉族人群 T2D 的关系，进行了一项荟萃分析，纳入了来自五项独立研究的 3080 例 T2D 患者和 3029 例对照。使用随机效应模型估计 KCNJ11 E23K 基因多态性与 T2D 之间关联的合并优势比（OR）及其相应的 95%置信区间（95%CI）。
在合并的中国汉族人群中，通过等位基因遗传模型（OR：1.21，95%CI：1.04-1.40，P = 0.01）和隐性遗传模型（OR：1.44，95%CI：1.25-1.65，P < 0.00001）观察到 KCNJ11 E23K 基因多态性与 T2D 之间存在显著关联。相比之下，在显性遗传模型（OR：0.66，95%CI：0.41-1.07，P = 0.09）中未观察到 KCNJ11 E23K 基因多态性与 T2D 之间存在显著关联。
KCNJ11 E23K 基因多态性与中国汉族人群的 T2D 风险相关。
