维拉帕米对应激大鼠胃钙水平的抗溃疡作用。

The antiulcer effect of verapamil in relation to gastric calcium levels in stressed rats.

作者信息

Koo M W, Cho C H, Ogle C W

机构信息

Department of Pharmacology, Faculty of Medicine, University of Hong Kong.

出版信息

Pharmacol Biochem Behav. 1989 Sep;34(1):73-6. doi: 10.1016/0091-3057(89)90355-9.

DOI:10.1016/0091-3057(89)90355-9

PMID:2516633

Abstract

The antiulcer effect of verapamil, and its relationship to stomach calcium levels, were examined in rats restrained at 4 degrees C (stress). Stress for 2 hr significantly increased muscle calcium and induced mucosal ulceration in the gastric glandular segment; calcium concentrations in the glandular mucosa and serum were unaffected. Verapamil or calcium gluconate given 30 min before stress prevented the rise in gastric muscle calcium, and attenuated ulcer severity. Bis(beta-aminoethylether)-NNN'N'-tetra-acetic acid (EGTA) pretreatment, however, further elevated stomach muscle calcium and markedly worsened lesion formation. These findings suggest that increased stomach muscle calcium could be a causal factor in stress-induced gastric glandular ulceration.

摘要

在4℃束缚（应激）的大鼠中研究了维拉帕米的抗溃疡作用及其与胃钙水平的关系。应激2小时显著增加了肌肉钙含量，并在胃腺段诱发了黏膜溃疡；腺黏膜和血清中的钙浓度未受影响。在应激前30分钟给予维拉帕米或葡萄糖酸钙可预防胃肌钙的升高，并减轻溃疡严重程度。然而，双（β-氨基乙基醚）-NNN'N'-四乙酸（EGTA）预处理进一步提高了胃肌钙水平，并显著加重了损伤形成。这些发现表明，胃肌钙增加可能是应激诱导的胃腺溃疡的一个病因。