Calcium channel blockers prevent stress-induced ulcers in rats.
作者信息
Yegen B C, Alican I, Yalçin A S, Oktay S
机构信息
Department of Biochemistry, Marmara University, School of Medicine, Haydarpasa, Istanbul, Turkey.
出版信息
Agents Actions. 1992 Jan;35(1-2):130-4. doi: 10.1007/BF01990962.
PMID:1509972
Abstract
Gastric mucosal damage induced by cold and restraint stress caused increase in gastric lipid peroxidation (LP) and decrease in gastric glutathione levels. Two calcium-channel blockers, verapamil and nicardipine, prevented stress-induced increase in gastric LP, as well as ulcer formation. Both calcium-channel blockers protected against stress-induced ulcers, and inhibition of LP may be among their mechanisms of action.
摘要
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